Efficacy of dermabrasion along with topical 1% 5-fluorouracil in 25 patients of vitiligo

Balaji, A P (2012) Efficacy of dermabrasion along with topical 1% 5-fluorouracil in 25 patients of vitiligo. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND: Vitiligo is a common pigmentary disorder of the skin with much prejudice and taboos.Various therapeutic approaches are available at present, which includes topical and systemic steroids, photo chemotherapy with psoralens, narrow band UVB therapy, and calcineurin inhibitors. In addition to medical therapies various surgical procedures are available for patients with stable vitiligo. Among the various surgical modalities, therapeutic dermabrasion with topical 5- fluorouracil application over stable vitiligo patch had shown good results in a short duration in various studies, either alone or in combination and seems to be have less side effects. AIM OF THE STUDY: To evaluate the efficacy of dermabrasion with topical 1% 5-fluorouracil in patients with stable vitiligo patches and to assess the feasibility of this procedure in day to day practice. METHODOLOGY: This was one year prospective study done on twenty five patients attending Department of Dermatology at Coimbatore Medical College Hospital, Coimbatore .Both men and women of age ranging from 15-60 years of with clinical diagnosis of stable vitiligo of more than 2 year duration were included in the study. Patients with actively spreading vitiligo , those with acrofacial and mucosal vitiligo, pregnant and lactating women , childrens, diabetic patients, those currently undergoing other topical or systemic therapy for vitiligo, patients with history of keloidal tendency ,bleeding diathesis and koebner phenonmenon were excluded from the study. The procedure of dermabrasion with topical 5 fluorouracil was done for these patients in first 6 months ,with follow up of the patient for next 6 months. RESULT: At the at the end of 6 months, out of 25 patients 4 did not turn for follow up. Partial repigmentation was observed in six patients (28.6%) and total repigmentation in fifteen Patients (71.4%). CONCLUSION: Dermabrasion along with topical 5 fluorouracil can be used as a simple office procedure, in repigmenting localised stable vitiligo, which is very economical & brings early regimentation without any significant side effects.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Dermabrasion ; 5 Fluorouracil ; stable vitiligo.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 21 Jun 2018 14:23
Last Modified: 22 Jun 2018 03:25
URI: http://repository-tnmgrmu.ac.in/id/eprint/8562

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