Saravanan, K (2016) A prospective randomized control study on intracuff alkalized lignocaine reduces sedative/analgesic requirements for mechanically ventilated patients in a tertiary care hospital. Masters thesis, Madras Medical College, Chennai.
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Abstract
OBJECTIVES: This study is to investigate the effect of intracuff alkalised Lignocaine in reducing the requirement of analgesia in post-operative patients requiring ventilator support and also to analyse patient-ventilator interaction. MATERIALS AND METHODS: This prospective randomised control study was conducted at the Institute of Anaesthesiology, Madras Medical College, Chennai. The study population included fifty patients. Patients were randomly assigned into two groups Group A and Group B. Group A (Intervention group) were administered intracuff alkalised Lignocaine (4% Lignocaine + 8.4% Sodium bicarbonate). Group B (Control group) were administered intracuff normal saline. All fifty patients were given Fentanyl infusion in a dose of 75μg/hr. The total requirement of fentanyl (25μg) bolus dose, when the patients Behavioural pain Scale was ≥5 was calculated during the first 24 hours. RESULTS: The requirement of Fentanyl bolus dose in patients with intracuff Lignocaine was less than that of the control group who were administered intracuff normal saline. The frequency of cough and ineffective trigger was lower in patients with intracuff alkalised Lignocaine compared to patients with intracuff normal saline. CONCLUSION: This study has documented significant reduction in the requirement of analgesia in patients with intrauff alkalised Lignocaine and also decreased frequency of ineffective trigger which implies better endotracheal tube tolerance and patient compliance.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | intracuff alkalized lignocaine ; sedative/analgesic requirements ; mechanically ventilated patients ; tertiary care hospital ; prospective randomized control study. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 15 Jun 2018 03:31 |
| Last Modified: | 15 Jun 2018 14:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8473 |
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