Arun Prasad, S (2016) The usefulness of diffusion weighted imaging in cholesteatoma diagnosis and postoperative pathologic correlation. Masters thesis, Madras Medical College, Chennai.
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Abstract
Middle ear cholesteatomas consist of ectopic keratinized epithelial tissue that grows inside the mucosa-lined middle ear cavity and desquamates, accumulating keratin and epithelial debris leads to bone erosion. Bony erosion can result in destruction of the ossicles, creating conductive hearing loss, labyrinthine fistulas with sensorineural hearing loss and vertigo, facial nerve canal erosion and facial paralysis, and rare intracranial complications, such as meningitis and abscess Diffusion-weighted imaging is a technique that measures the molecular diffusion of water (Brownian motion) within the tissues, which can be quantified using Apparent Diffusion co-efficient (ADC). Diffusion-weighted imaging is highly specific due to the high keratin content of cholesteatomas.Newer techniques allow detection of smaller lesions and may be sufficient to replace second-look surgery in patients with prior cholesteatoma resection .Thus early detection avoids unnecessary complications and can avoid second looking surgery. DWI is superior to conventional T2 sequence in detecting the cholesteatomas. HRCT and MRI are complementary to each other in diagnosing cholesteatomas. In preoperative cases HRCT has high diagnostic accuracy and MRI is usually used to confirm the diagnosis whereas in postoperative cases HRCT is highly non specific and MRI plays significant role in diagnosing cholesteatomas.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Diffusion Restriction ; Apparent Diffusion Coefficient ; Second Look Surgery. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Punitha K |
| Date Deposited: | 03 Jul 2017 11:19 |
| Last Modified: | 06 Nov 2018 19:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/843 |
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