Anuradha, G (2010) Ferroxidase/albumin ratio-diagnostic and prognostic marker of Pulmonary Tuberculosis. Masters thesis, Stanley Medical College, Chennai.
|
Text
201300210anuradha.pdf Download (1MB) | Preview |
Abstract
Tuberculosis is a curable infectious disease causing significant morbidity and preventable deaths worldwide. This disease usually affects the Lungs , although other organs are involved in up to one-third of cases. India , China , Indonesia , South Africa and Nigeria rank first to fifth Countries respectively in terms of absolute number of cases. By recent survey in India both pulmonary and extra-pulmonary TB cases are endemic in Indian subcontinent . India has the highest TB burden in the world in terms of absolute number of incident Cases . To make the situation worse , TB has formed a lethal partnership with HIV. Untreated HIV infection is the greatest risk factor for progression from Latent Tuberculosis infection to TB disease . Hence timely screening for TB infection and treatment in HIV-infected people is necessary to increase the chances of survival and reduce the transmission of TB in the community. In India broad- spectrum antibiotics are being prescribed inappropriately leading on to MDR-TB. Studies have reported that MDR-TB is significantly higher among treatment failures.This can be prevented by early referral for culture. Nowadays, Radiometry using BACTEC instrument is used to reduce the diagnostic time in cultured specimens. But still, using this technique, organisms can be detected only after 7 to 8 days in smear positive patients and 16 to20 days in smear negative patients. 2 While the treatment of TB is considered one of the most cost-effective interventions in DOTS programme, we are still without a fast and simple diagnostic test that would be applicable in high-burden but resource-poor settings. 54 CONCLUSION: Pulmonary Tuberculosis is a communicable disease of global importance. The present study on PTB patients (both freshly diagnosed and treated cases) showed that there was highly significant increase in the serum Ferroxidase / Albumin ratio level in freshly diagnosed PTB cases which on ATT treatment falls back to near normal level on comparison with apparently healthy individuals. The serum F/A ratio level is useful in predicting the course of PTB infection. It shows the degree of tuberculosis activity and thus it may serve as a guide in the management of PTB disease. A favorable course will always be associated with a tendency towards the near normalization of serum F / A ratio and the patient is not considered healed unless the serum F/A ratio is near normal. The method employed to estimate serum Ferroxidase ( by end point measurement method using ferrous ions ) and serum Albumin ( by Bromocresolgreen dye binding method ) level are simple, rapid and cost effective . Hence serum F / A ratio can feasibly be incorporated as a biochemical marker to assist in diagnosis and prognosis of PTB.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Ferroxidase ; albumin ; ratio-diagnostic ; prognostic marker ; Pulmonary Tuberculosis. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 04 Jul 2017 01:10 |
| Last Modified: | 04 Jul 2017 01:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/837 |
Actions (login required)
 |
View Item |
