Laryngeal Preservation in Advanced (Stage III/IV) Carcinoma of the Larynx

Jose, Paul (2010) Laryngeal Preservation in Advanced (Stage III/IV) Carcinoma of the Larynx. Masters thesis, Cancer Institute (WIA), Chennai.


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INTRODUCTION: Laryngeal cancer is a malignancy associated with significant psychosocial consequences as impairment of laryngeal function from disease and/or its treatment results in gross disturbances in breathing, speech, and swallowing with profound impact on the patient’s lifestyle and self esteem. The successful management of laryngeal cancer is dependent as much upon individualizing the plan of management to suit the particular patient and his/her expectations, as on close co-operation among members of a multidisciplinary team. AIM OF THE STUDY: The aim of the study was to analyse the treatment methods, outcomes and laryngeal preservation rates achieved in advanced (stage III/IV) squamous cell carcinoma of the larynx. PATIENTS AND METHODS: One hundred patients registered at the Cancer Institute during the years 2006-2008 with advanced, stage III/IV (as per the AJCC/TNM classification), squamous cell carcinoma of the larynx, who were taken up for treatment with curative intent, were included in this study. Patients who had already undergone treatment and presented with a residue or recurrence, those with distant metastasis, those with histological types other than squamous cell carcinoma as well as those with uncontrolled intercurrent disease (e.g., diabetes, hypertension, thyroid disease) and / or known chronic infection with HIV or viral hepatitis were not taken up for the study. CONCLUSION: Concurrent chemoradiation offers comparable oncological outcomes for patients with advanced carcinoma of the larynx while preserving their voice and thus offering a better quality of life.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Laryngeal Preservation ; Advanced (Stage III/IV) Carcinoma ; Larynx.
Subjects: MEDICAL > Radio Therapy
Depositing User: Punitha K
Date Deposited: 23 May 2018 16:44
Last Modified: 23 May 2018 16:44

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