Saritha, D (2010) Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer. Masters thesis, Cancer Institute (WIA), Chennai.
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Abstract
BACKGROUND: At Cancer Institute, the usual protocol for locally advanced rectal cancer is neo-adjuvant chemo-radiation followed by surgery. The chemotherapy schedule used is Mitomycin-c and 5-Flurouracil concurrently with radiation. In order to analyze the effect of this multimodal approach, this study was planned. AIM OF THE STUDY: To study the outcome of patients with locally advanced rectal cancer treated with neo-adjuvant chemotherapy and radiotherapy at the Institute from 2002 to 2006. MATERIAL AND METHODS: 224 patients with locally advanced (T2-T4/N0-N2 disease), pathologically confirmed adenocarcinoma of the rectum, without detectable distant metastasis at presentation, and who were registered at the Institute between January 2002 to December 2006, were taken up for the study. Those patients who had already undergone specific treatment for the rectal cancer were not included. Pre-treatment Workup: The pre-treatment workup included: 1. Detailed history, 2. Complete physical examination including detailed rectal examination, 3. Hematology and biochemistry, 4. Chest X Ray, ECG and Echo, 5. Colonoscopy, 6. Histopathological examination, 7. CT Scan Abdomen and pelvis, 8. CEA. RESULTS: A total of 224 patients with locally advanced (T2-T4/N0-N2 disease), pathologically confirmed adenocarcinoma of the rectum, without detectable distant metastasis, registered at the Institute between January 2002 to December 2006, were taken up for this study. CONCLUSION: Neoadjuvant chemoration followed by radical surgery has shown very satisfactory results in the management of locally advanced rectal cancers.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Neoadjuvant Chemoradiation ; Locally Advanced Rectal Cancer. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Punitha K |
| Date Deposited: | 23 May 2018 16:52 |
| Last Modified: | 23 May 2018 16:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8093 |
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