Vijayalakshmi, M (2015) A Prospective Comparative Clinical Study of Atorvastatin and Atorvastatin with Vitamin D3 on Lipid Profile in Various Patient Population. Masters thesis, Madurai Medical College, Madurai.
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Abstract
OBJECTIVE: To compare the effect of Atorvastatin and vitamin D3 combination with Atorvastatin on lipid profile in various patient population. METHODOLOGY: The study was conducted in outpatient department of General Medicine, Nephrology, Madurai Medical College, Madurai, between February 2013 to August 2014. 120 patients with Dyslipidemia were selected based on measurement of lipid profile. Out of 120 patients, 60 patients were treated with atorvastatin 10 mg/day orally and the remaining 60 patients were treated with atorvastatin 10mg and vitamin D3 1000IU/day orally. In atorvastatin group, 30 were Hypertensive and 30 had chronic kidney disease (CKD). In atorvastatin vitamin D3 group 30 were Hypertensive and 30 had CKD. The plasma lipid profile was assessed at the beginning, third month and at the end of sixth month. The results were tabulated and analyzed statistically RESULTS: All the patients were followed up till the end of the study. There were no dropouts. At the end of sixth month the mean total cholesterol was significantly reduced in atorvastatin vitamin D3 group than in atorvastatin group with ‘p’ value <0.001. The mean Low Density Lipoproteins, Triglycerides, and very Low Density Lipoproteins were significantly reduced in atorvastatin vitamin D3 group than in atorvastatin group with ‘p’ value <0.001. The mean High Density Lipoproteins in atorvastatin vitamin D3 group was- 45.32 and in atorvastatin group was-44.28 with ‘p’ value <0.001. CONCLUSION: Fasting plasma lipid profile improved significantly in both groups. However the improvement was very high in the atorvastatin vitamin D3 group. The Atorvastatin and vitamin D3 treated group showed good response compared to atorvastatin treated group.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Atorvastatin ; Dyslipidemia ; lipid profile ; vitamin D3. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 24 May 2018 17:52 |
| Last Modified: | 27 May 2018 10:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8087 |
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