Lenin, R (2015) Alternate Regime in Dyslipidemia. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: Dyslipidemia, which includes hypercholesterolemia and reduced level of HDL-C are the major reason for increased risk of atherogenesis. The sedentary life style &genetic disorders with diets rich in saturated fat & cholesterol contributes this non communicable disease. The drugs most commonly used for dyslipidemia are statins and fibrates. Though the therapy may be started with either statin or fibrates, ultimately most of these patients require both the drugs or some other combination therapy. METHODS: Eligible patients with dyslipidemia were randomly allotted into 2 equal groups- daily regime group (group 1) and alternate regime group (group 2). Patients in group 1 received atorvastatin 10 mg and fenofibrate 160 mg daily and group 2 received on alternate days, respectively for 6 weeks & follow up by 12th week. Mean percentage change from baseline in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), VLDL-C, HDLC and TC-HDL ratio, incidence of adverse effects, and cost-effectiveness were compared in both the groups. RESULTS: Among 93 patients screened, 60 were randomized into 2 groups as group1 & 2 with 30 patients in each. The TC, LDL-C, TGs, VLDL-C decreased by 46.03%, 47.23%, 58.67%, and 45.39% in alternate regime group and by 46.67%, 48.01%, 59.88%, and 46.31% in daily regime group. The HDL-C levels increased by 29.32% in alternate day therapy group compared to 32.11% in daily therapy group. No statistically significant difference was seen between both the groups in mean percentage change in lipid parameters from baseline to end of 12 weeks. TC-HDL ratio was 3.50 in group1 and 3.54 in group 2.Incidence of adverse events were reasonably less in alternate day therapy group. CONCLUSION: Alternate regime of atorvastatin 10 mg on one day & fenofibrate 160 mg on other day is equally efficacious to daily regime of both atorvastatin10 mg and fenofibrate 160 mg with better cost effectiveness & better patient compliance in patients with secondary dyslipidemia.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Alternate regime ; atorvastatin ; fenofibrate ; cost-effectiveness ; dyslipidemia. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 24 May 2018 17:51 |
| Last Modified: | 27 May 2018 10:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8085 |
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