Brainstem Auditory Evoked Responses in Newly Diagnosed Hypothyroid Individuals

Roseline Jesintha, V (2015) Brainstem Auditory Evoked Responses in Newly Diagnosed Hypothyroid Individuals. Masters thesis, Coimbatore Medical Collegel, Coimbatore.


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BACKGROUND: Hypothyroidism is one of the most common endocrine disorder, affecting the females predominantly than males. Thyroid hormone deficiency affects almost all organ system of our body including auditory pathway. Sensori neural hearing loss is the most common otolaryngological manifestations of thyroid dysfunction. Evoked potentials are the best methods which have been used extensively in the study of brain disturbances and to a lesser degree in metabolic diseases. Brainstem Auditory Evoked Response (BAER) is one of the method used for assessing the pathology in the brainstem auditory pathway. AIM AND OBJECTIVES: To evaluate the auditory sensory process in the brainstem by using Brainstem auditory evoked responses in the newly diagnosed hypothyroid individuals. Study Design: This is a Cross sectional study. Participants: Forty newly diagnosed hypothyroid females of 20 – 50 years were taken as cases and forty age matched females were considered as controls. The hypothyroidism was diagnosed by estimating the serum levels of free T3(fT3), free T4 ( fT4) and TSH. METHODOLOGY: After getting informed written consent, a thorough clinical assessment by detailed history, systemic and neuro - otological examination have been done in both cases and controls. The absolute latencies and interpeak latencies of BAER were recorded using Neuroperfect EMG 2000 system with installed BAER in the research laboratory, Department of Physiology, Coimbatore Medical College, Coimbatore and the data were analyzed by student unpaired t test. RESULTS: The absolute latencies I, III, V and inter peak latencies I- III, III-V, I – V were significantly prolonged in newly diagnosed hypothyroid females (p < 0.0001) and also there was direct correlation between thyroid profile changes and the BAER latencies. CONCLUSION: The results of the present study suggests that hypothyroidism affects the auditory pathway in diffuse pattern and the involvement of auditory pathway in thyroid hormone deficiency can be identified by using BAER at an early stage itself. The prolongation of BAER latencies in newly diagnosed hypothyroid females was due to defective myelination of neural pathways and diminished cerebral metabolism. Hence it may be worthwhile to add the BAER recordings in the list of screening tools for a more accurate and early assessment of neurological involvement in hypothyroid individuals.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hypothyroidism ; Brainstem Auditory Evoked Responses ; Sensorineural hearing loss.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:47
Last Modified: 27 May 2018 12:48

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