Serum Leptin Level and Its Association with Blood Pressure, Body Mass Index, Waist Hip Ratio and Waist Height Ratio

Malarvizhi, G (2015) Serum Leptin Level and Its Association with Blood Pressure, Body Mass Index, Waist Hip Ratio and Waist Height Ratio. Masters thesis, Coimbatore Medical Collegel, Coimbatore.

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Abstract

BACKGROUND: Leptin is a product of Ob gene secreted from adipose tissue. It is a key neuroendocrine hormone regulating food intake, metabolism, and fat accumulation, and it may also affect blood pressure and contribute to hypertension through sympathetic activation in the vasculature or at the renal level. Hyperleptinemia also seen in obesity, which is a major comorbid condition of hypertension. AIM OF THE STUDY: To study the relationship between serum leptin level and Blood pressure in association with Age, Gender, Body mass index, Waist hip ratio and Waist height ratio. MATERIALS AND METHODS: Study group : 48 hypertensive patients (26 males, 22 females) in the age group of 35-75 years. Control group include 42 normotensive persons (22 males, 20 females) in the same age group. After recording the history, clinical examination and blood pressure, weight (in Kg), height (in cms) waist circumference (in cms) and hip circumference (in cms) were measured. BMI, waist hip ratio and waist height ratio were calculated. Blood sample was collected under strict aseptic precaution after overnight fasting and then centrifuged to collect the serum. Serum leptin level was estimated by using KAP 2281 Human leptin ELISA kit. The values were statistically analyzed by chi square tests and student ‘t’ test. RESULT: In the present study, serum leptin level was significantly increased with the p value of < 0.0001 in hypertensive patients (8.15 ± 2.68) when compared to normotensive persons (1.74 ± 1.04). And also it was found that serum leptin level positively correlated with systolic blood pressure (P < 0.0268), age (P< 0. 0001), BMI (P <0.0467), waist hip ratio (P<0.0001) and waist height ratio (P <0.0001). CONCLUSION: From this study it was concluded that, there is a strong positive correlation between serum leptin level and high blood pressure, age, body mass index, waist hip ratio and waist height ratio.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Leptin ; blood pressure ; body mass index ; waist hip ratio ; waist height ratio.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:47
Last Modified: 27 May 2018 12:44
URI: http://repository-tnmgrmu.ac.in/id/eprint/8069

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