Bhuvaneswari, S (2015) Correlation between Plasma Fibrinogen and Glycosylated Hemoglobin in Type II Diabetes Mellitus Patients. Masters thesis, Coimbatore Medical Collegel, Coimbatore.
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Abstract
BACKGROUND: Type II diabetes mellitus occurs due to deficient insulin production in the setting of insulin resistance. In India, more than 62 million people are diagnosed as having diabetes. The risk of developing coronary artery disease is 2-4 fold high in diabetics and this excess risk was not fully explained by classical risk factors like smoking, hypertension and dyslipidemia. Fibrinogen in its high level involved in all stages of atherogenesis and considered as an important cardiovascular risk factor. AIM AND OBJECTIVES: To compare the plasma fibrinogen level between type II diabetics and healthy individuals. To correlate the plasma fibrinogen level with HbA1c value in type II diabetic patients. MATERIALS AND METHODS: This is cross sectional type of study. 75 type II diabetic patients of age between 40-60 years taken as study group. 75 age and sex matched healthy individuals taken as control group. Study subjects were selected from the outpatient department of Diabetology, CMCH. Patients with history of systemic hypertension, smoking, vascular complications of diabetes, infectious and inflammatory conditions were excluded from the study. Blood sample was taken and analysed for plasma fibrinogen and HbA1c by turbidimetric immunoassay method. RESULTS: Statistical analysis was done by using student ‘t’ test and pearson correlation coefficient. In the present study, mean plasma fibrinogen level was significantly increased (p <0.0001) in diabetic patients (276.6 ± 87) when compared to control group (160.3 ± 49). significantly increased ( p <0.0001) plasma fibrinogen level was observed in diabetics with HbA1c of >7% (334.2±77) and also positively correlated with HbA1c value (r=0.8166). CONCLUSION: In the present study, increased plasma fibrinogen level (upper limit of normal range) was observed in diabetic patients having HbA1c of more than 7%. It could be due to advanced glycation end products mediated endothelial injury, apoprotein - a and increased amount of glycosylated fibrinogen. Elevated plasma fibrinogen along with other blood clotting factors produce hypercoagulable state in diabetes mellitus. Increased plasma fibrinogen also involved in all stages of atherogenesis, which results in formation of occlusive thrombus. So the measurement of plasma fibrinogen is considered as an important tool to assess cardiovascular risk in diabetic patients.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | diabetes ; fibrinogen ; HbA1c ; cardiovascular risk factor. |
| Subjects: | MEDICAL > Physiology |
| Depositing User: | Punitha K |
| Date Deposited: | 24 May 2018 17:47 |
| Last Modified: | 27 May 2018 12:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8068 |
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