Effects of Protein Energy Malnutrition on Peripheral Nerve Conduction and Auditory Evoked Potential Responses in Children

Rubha, S (2015) Effects of Protein Energy Malnutrition on Peripheral Nerve Conduction and Auditory Evoked Potential Responses in Children. Masters thesis, Thanjavur Medical College, Thanjavur.


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AIM OF THE STUDY: Protein energy malnutrition affects the myelination and growth of the nervous system. The aim of this study is to determine the effects of protein energy malnutrition on Peripheral nerve conduction & Auditory Evoked Potential Responses in children. MATERIALS AND METHODS: 40 study group & 40 control group children were selected for this study. Study group includes 40 malnourished children of 5 – 10 years of age from Raja Mirasudar Hospital, Thanjavur based on anthropometric measurements like weight for age & height for age. Control group consists of 40 normal children of same age group. Genetic & endocrine causes for short stature, children with ear pathology were excluded from the study. Informed written consent from the parents / guardians was obtained. Ethical committee approval was obtained before commensing the study. A detailed history & complete clinical examination were performed. Recording of BAER & NCS was done. Results were analysed statistically using student‟s „t‟ test. RESULT: There was a significant prolongation in wave I, II, III, IV latency , IPL I-III ,III-V & nerve conduction study showed reduced motor and sensory nerve conduction velocity ( p < 0.05 ) in children with Grade III malnutrition. Children with Grade I, II malnutrition showed significant prolongation in IPL I – III and reduced sensory nerve conduction velocity (p < 0.05). CONCLUSION: The present study shows significant alteration in Nerve Conduction Velocity & Brainstem Auditory Evoked Potential Responses in children with malnutrition which may be due to nutritional deficiency affecting myelination of peripheral nerves & Auditory Brainstem Pathways. Electrophysiological parameters like MNCV , SNCV , BAEP – Absolute peak latency of Wave I, II, III, IV and Interpeak latency I – III , III – V were recorded. Electrophysiological abnormalities depends on duration and severity of malnutrition. Severe and chronic malnutrition affects Nerve Conduction Velocity, BAEP – I, II, III, IV and IPL I – III, III – V findings. Mild to moderate malnutrition alters Sensory Nerve Conduction Velocity & BAEP – IPL I – III. Thus there is strong association between duration and severity of malnutrition with NCS & BAEP abnormalities. So these electrophysiological tests can be used to detect malnutrition at its early stage. Nutritional deficiency during development of brain has longlasting effect on learning abilities, psychomotor development, But whether it is reversible or irreversible after nutritional rehabilitation needs to be evaluated. With the help of advanced electrophysiological methods, the need for screening, early diagnosis, health education & initiating nutritional support at appropriate time will help the Children to improve their academic performance and to become a successful achiever in future.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Malnutrition Peripheral Nerve Conduction ; Interpeak latency ; Auditory Evoked Potential Response ; Children.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:46
Last Modified: 29 May 2018 04:40
URI: http://repository-tnmgrmu.ac.in/id/eprint/8065

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