Evaluation of Chronic Kidney Disease by Using Visual Evoked Potential and Uremic Markers

Shanmuga Priya, P (2015) Evaluation of Chronic Kidney Disease by Using Visual Evoked Potential and Uremic Markers. Masters thesis, Stanley Medical College, Chennai.

[img]
Preview
Text
200500215shanmuga_priya.pdf

Download (1MB) | Preview

Abstract

BACK GROUND: Chronic Kidney Disease is often unrecognized health problem due to less awareness, less health care facilities. Due to its progressive and irreversible course it may presents with serious complications involving all systems including the central nervous system of our body. AIM AND OBJECTIVE: The aim of the present study was to “evaluate the involvement of central nervous system (CNS) in Chronic kidney disease (CKD) patients by doing Visual Evoked Potentials (VEP) and the estimation of blood levels of uremic markers (Uremic neurotoxins) like Blood Urea, Serum Creatinine. Serum Parathyroid hormone (PTH) in comparison with age matched controls”. The objectives of the study were to determine the subclinical involvement of central nervous system in CKD patients by doing Visual Evoked Potentials and compare it with controls, to assess the uremic neurotoxin’s role in uremic encephalopathy by measuring the blood levels of uremic markers (uremic neurotoxins) like Blood Urea, Serum Creatinine, Serum Parathyroid hormone in CKD patients and compare it with controls, to find out the most vulnerable group of CKD patients by comparing the VEP parameters and blood levels of uremic markers (uremic neurotoxins) among the two CKD groups (CKD3-5 on medical therapy, CKD5D on dialysis and to find the correlation between the Visual Evoked Potential (VEPs) parameters and blood level of uremic marker in Chronic Kidney Disease (CKD) patients. MATERIAL AND METHODOLOGY: 60 diagonsed as CKD (30-CKD3-5, 30-CKD5D) were recruited from Department of Nephrology ,Stanley medical college,Chennai.30 normal subjects were recruited from Master health checkup, Stanley Medical College, Chennai. Ethical committee approval was obtained .Informed and written consent was obtained. After explaining the procedure, VEP recording was done with the RMS Polyrite apparatus. The blood investigation done for the measurement of uremic markers. RESULTS: Means, standard deviations, chi square and 'p' values were calculated by One way ANOVA and ‘t’ test. Chi-square test was used to experiment the importance of disparity among the consolidated (quantitative) variables. Prolonged latencies with highly significant p-value (p<0.0001) of all VEP parameters and reduced amplitude with significant p-value (<0.05) was noticed. Elevated blood levels of all uremic markers was noticed. This altered variables was higher among CKD3-5 with significant p-value(p<0.05) in comparison with CKD 5D. Correlation was noticed but not significant between VEP parameters and blood levels of uremic markers. DISCUSSION: The altered parameters of VEP and Uremic markers may predict the subclinical involvement of central nervous system involvement in CKD patients. CONCLUSION: In order to reduce the morbidity and mortality in CKD patients, VEP recording and the estimation of blood levels of uremic markers may used as a screening tool to identify the subclinical involvement of central nervous system in future.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Chronic kidney disease ; Uremic markers ; Visual evoked potentials.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:44
Last Modified: 27 May 2018 11:42
URI: http://repository-tnmgrmu.ac.in/id/eprint/8061

Actions (login required)

View Item View Item