A Study of Cognitive Evoked Potential and Arterial Oxygen Saturation in Stable COPD Patients

Rowena, Victor (2015) A Study of Cognitive Evoked Potential and Arterial Oxygen Saturation in Stable COPD Patients. Masters thesis, Stanley Medical College, Chennai.


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BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex multicomponent disease which is associated with cognitive impairment due to neuronal damage mediated by hypoxia. Cognitive impairment affects the self-management, clinical management and pulmonary rehabilitation of COPD subjects. Progressive impairment of the auditory P300 evoked potential with prolonged latency occurs with increasing severity of COPD. So routine screening of COPD patients for cognition is helpful in assessing the progression of the disease. AIM OF THE STUDY: To assess the cognitive function and to correlate it with arterial oxygen saturation in stable COPD patients and age matched controls. OBJECTIVE: To assess cognitive functions in stable COPD patients and age-matched healthy controls using Cognitive evoked potential (CEP) study, Mini mental status examination (MMSE) and Stroop test to correlate them with Arterial oxygen saturation ( SpO2) using Pulse oximetry and Arterial oxygen tension ( PaO2) by arterial blood gas analysis. MATERIALS AND METHODS: The study population were 50 Stable COPD patients and 50 controls. They were subjected to MMSE, Stroop test, and CEP study and SpO2 measured by Pulse oximetry. In addition, Arterial blood gas analysis was done for the patients to measure PaO2. The data were analyzed using Mean, Standard deviation, Independent t-test, ANOVA and Tukey post hoc test and pearson's correlation were used for analysis. The mean difference was significant when p < 0.05 level. RESULTS: In stable COPD patients, MMSE score was significantly lower, interference score was significantly increased in Stroop test and prolonged N100,P300 latency and reduced P300 amplitude in CEP study than in controls. SpO2 by pulse oximetry shows significant decrease in patients than in the controls. There is positive correlation between P300 amplitude and PaO2 in the patients. CONCLUSION: There is significant cognitive impairment in Stable COPD patients as evidenced by MMSE, Stroop test, and CEP study. We recommend CEP study as a screening tool in Stable COPD patients to detect early cognitive impairment so that timely intervention can be planned to improve the quality of their life.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Stable COPD patients ; Cognitive evoked potential ; P300 ; MMSE ; Stroop test ; Cognition.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:44
Last Modified: 27 May 2018 11:57
URI: http://repository-tnmgrmu.ac.in/id/eprint/8060

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