Evaluation of Brainstem auditory evoked potential and serum Interleukin-1beta levels in patients with generalized tonic clonic seizures

Savitha, G (2015) Evaluation of Brainstem auditory evoked potential and serum Interleukin-1beta levels in patients with generalized tonic clonic seizures. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: Epilepsy is a neurological disorder characterized by abnormal changes in the brain’s electrical potentials. Brainstem Auditory Evoked Potential (BAEP) is an important clinical tool in studying the electrophysiological phenomena of neural excitation, conduction and transmission across the auditory pathway. It has been widely used for the early detection of neural conduction irregularities in auditory pathway. Using BAEP, we can easily detect the early changes occurring in the auditory pathway in Generalized Tonic Clonic Seizure (GTCS) patients even before the clinical manifestation of hearing impairment occurs so that proper measures to intervene the disease process at the earliest possible is achieved to provide a better quality of life for GTCS patients. AIM OF THE STUDY: 1. To determine the functional integrity of auditory pathway in patients with GTCS by recording brainstem auditory evoked potential. 2. To assess serum Interleukin -1 beta levels in these patients. 3. To find the correlation between serum Interleukin-1 beta level and Brainstem auditory evoked potential in patients with GTCS. MATERIALS AND METHODS: 30 patients with GTCS of both sexes in the age group 20-40 years without any clinical evidence of hearing impairment were included in the study. Controls were age, sex and BMI matched healthy population. Both the controls and GTCS patients were subjected to BAEP and serum interleukin-1beta levels were also measured. The data were analyzed by Student ‘t’ test. RESULT: GTCS patients showed significant differences in wave III, V absolute latency and I-III, I-V IPL of BAEP. The interleukin-1β levels were significantly prolonged in GTCS patients as compared to control population suggesting the contribution of this cytokine in epileptogenesis. CONCLUSION: There was significant prolongation of central conduction time in GTCS patients even though there was no clinical evidence of hearing impairment assessed by pure tone audiogram prior to the study. Hence BAEP can be utilized as an objective electrophysiological tool to evaluate the functional integrity of auditory pathway from the external ear to lower brainstem.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Generalized tonic clonic seizures ; Brainstem auditory evoked potential ; Absolute latency ; Interpeak latency.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 24 May 2018 17:43
Last Modified: 27 May 2018 12:17
URI: http://repository-tnmgrmu.ac.in/id/eprint/8058

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