A Study of Polysomnography and Serum Ghrelin Levels in Patients with Generalized Tonicclonic Seizures

Meenakumari, K (2015) A Study of Polysomnography and Serum Ghrelin Levels in Patients with Generalized Tonicclonic Seizures. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: There is a complex relationship between sleep and epilepsy. They are reciprocal to each other. METHOD: A total of 30 generalized tonic clonic seizure patients and 30 controls were subjected to polysomnography. It simultaneously records the three physiological measures that define the stages of muscle tone, recorded through Electromyogram (EMG), eye movements, recorded through the Electrooculogram (EOG) and brain activity, recorded through the Electroencephalogram (EEG), and compared with equal number of normal individuals. Ghrelin is peptide hormone, secreted from stomach. Its level was measured in the fasting state. Its level increased before food intake and decreased after food intake. RESULTS: The mean age of the study groups were comparable 31.10±5.6 for GTCS patients and 30.03±6.26 for control groups as well as body mass index for GTCS patients (26.89±0.99) and for control groups (26.30±1.46). In this study, sleep architectural changes, mainly prolonged stage I (18.35±2.85 for GTCS and 14.6±2.6 f0r control group)and stage II of NREM sleep and reduced REM sleep(63.93±13.21 for GTCS and 77.27±13.3 for control group) occurs in GTCS patients than comparative with control group leads to fragmentation of sleep. And also serum ghrelin levels were decreased in these patients. CONCLUSION: Sleep disturbances are more common in the epileptic patients. It will further worsening the seizure propensity. Identifying and treating these associated sleep problems, also an important part in the management of epilepsy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: ghrelin ; generalized tonic clonic seizures ; polysomnography.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 23 May 2018 17:47
Last Modified: 23 May 2018 17:47
URI: http://repository-tnmgrmu.ac.in/id/eprint/8056

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