A Study of Heart Rate Variability and Serum Insulin Levels in Patients with Parkinson’s Disease

Girijasivam, S P (2015) A Study of Heart Rate Variability and Serum Insulin Levels in Patients with Parkinson’s Disease. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: Parkinson’s disease is the commonest neurodegenerative illness affecting the world population. Autonomic dysfunction and non-motor symptoms (NMS) in Parkinson’s disease (PD) are frequent, disabling and reduce quality of life of patient. The prevalence of insulin resistance might play a role in the etiopathogenesis of Parkinsonism. AIM AND OBJECTIVE: There is a paucity of studies on autonomic dysfunction in PD in Indian population. The study aimed to evaluate cardiac autonomic activity in Parkinson’s disease patients with HRV parameters and study the prevalence of insulin resistance in Parkinsonism and correlate the findings with duration of Parkinson’s disease. MATERIALS AND METHODS: We evaluated autonomic function in 30 diagnosed patients of Parkinson’s disease (age 40-70 years) and 30 healthy age & sex matched controls by Resting Heart Rate Varaibility and evaluated insulin resistance by measuring serum insulin levels with ACCUBIND Insulin test system. The results were analysed with SPSS version 17. Both the results were correlated with each other and with the duration of disease. RESULTS: Statistically significant reduced HRV and both sympathetic and Parasympathetic failure have been found in Parkinson’s disease patients when compared to age and sex matched controls. The prevalence of insulin resistance is also significantly high in Parkinson’s disease. A significant negative correlation was found between the LF (ms2),HF (ms2) values and duration of disease in this study. CONCLUSION: Abnormalities of autonomic function and prevalence of insulin resistance were integral and present across all the stages of PD patients which may be associated with the adverse cardiac events. Early recognition and treatment of these may decrease morbidity and improve quality of life of PD patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Autonomic dysfunction ; Parkinson’s disease ; Heart Rate Variability ; Insulin resistance.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 23 May 2018 17:39
Last Modified: 23 May 2018 17:39
URI: http://repository-tnmgrmu.ac.in/id/eprint/8054

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