A Study on Mycological Profile of Onychomycosis in Diabetic Patients in a Tertiary Care Hospital and their Antifungal Susceptibility Pattern

Gomathi Chitra, A (2015) A Study on Mycological Profile of Onychomycosis in Diabetic Patients in a Tertiary Care Hospital and their Antifungal Susceptibility Pattern. Masters thesis, Madras Medical College, Chennai.

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Abstract

INTRODUCTION: Onychomycosis among diabetics are very common and increases the risk of developing secondary bacterial infection and cellulitis if untreated. AIMS AND OBJECTIVES: 1. To identify the etiological fungal pathogens in onychomycosis among diabetic patients. 2. To determine the epidemiological profile of pathogens and to study the antifungal susceptibility pattern of the isolates. MATERIALS AND METHODS: The study was carried out in the Institute of Microbiology in association with Department of Dermatology and Institute of Diabetology, Madras Medical College, RGGGH, Chennai during October 2013 to September 2014.Nail scrapings were collected from all known diabetic patients above the age of 18 years who were diagnosed with onychomycosis irrespective of their glycemic status. The samples were subjected to direct examination and culture. The fungal pathogens were identified and their antifungal susceptibility pattern was done. RESULTS: The culture and KOH positivity rate was 46.28% and 70.29% respectively.Candida species was the most common isolate (39.50%) followed by nondermatophytic moulds (34.58%) and dermatophytes(12%). Candida parapsilosis (75%) was the most common etiological agent among Candida species. Among non-dermatophytic moulds,Fusarium species was the most etiological agent.Candida species were common among females in finger nail infection. All the Candida species were sensitive to azole drugs.Voriconazole was found to have lower MIC range in non-dermatophytic moulds except Fusarium species.Terbinafine was found to have lower MIC range in case of dermatophytes. CONCLUSION: This study highligts the role of C.parapsilosis as a emerging pathogen in diabetic patients and fluconazole still remains as an effective antifungal agent among the Candida species.Non-dermatophytic moulds should not be merely considered as contaminants and the diagnosis should be confirmed by repeated sampling.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Mycological Profile ; Onychomycosis ; Diabetic Patients ; Tertiary Care Hospital ; Antifungal Susceptibility Pattern.
Subjects: MEDICAL > Microbiology
Depositing User: Punitha K
Date Deposited: 23 May 2018 02:42
Last Modified: 27 May 2018 04:32
URI: http://repository-tnmgrmu.ac.in/id/eprint/8021

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