Dengue: A Clinicohaematological Profile and Role of Platelet Transfusion in its Management

Evelyn Angel, S (2015) Dengue: A Clinicohaematological Profile and Role of Platelet Transfusion in its Management. Masters thesis, Sree Mookambika Institute of Medical Sciences, Kulasekharam.


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AIM OF THE STUDY: Dengue is a major health problem and ranks as the most important mosquito borne viral disease in the world. Several factors have been attributed to increased morbidity and mortality in dengue with altered haematological and coagulation parameters playing an important role. The present study was done to analyze the haematological findings and correlate the same with the clinical course ,to evaluate the role of platelet count in predicting outcome in dengue patients and to observe the number of serologically dengue positive patients requiring platelet transfusion and its outcome. MATERIALS AND METHODS: Fifty patients admitted in Sree Mookambika Institute of Medical Sciences Hospital with fever and IgM and or NS1 positivity were selected. Various haematological, biochemical and clinical parameters were studied along with the role of platelet transfusion and the outcome noted. Statistical analysis was done for the various parameters. RESULTS: Out of the 50 cases in this study all the cases had fever (100%), headache (100%), myalgia (86%), hepatomegaly (52%) and splenomegaly in (48%). 26% had ascites, rise of haematocrit and pleural effusion was seen in 16% each. Leukopenia was seen in 73% of the cases, reversal of neutrophil lymphocyte ratio was seen in 27% of the cases. AST and ALT levels were raised with mean value being 106.08 IU/L and 118.54 IU/L. Platelet transfusion was indicated 86% of the cases.52% of the cases were transfused platelets on the first day.54%of the cases had 1-2 units of platelets transfused. 53.49% of the patients took 3 days to recover 3 days after transfusion of platelets. CONCLUSION: Fever with headache and presence of thrombocytopenia, leukopenia, reversal of neutrophil lymphocyte ratio with signs of capillary leak like ascitis, pleural effusion and rising haematocrit should raise strong suspicion of dengue fever. Platelet transfusion in cases of moderate to severe thrombocytopenia proved to be useful for an eventful and smooth recovery.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Dengue ; IgM ; Thrombocytopenia ; Leukopenia ; reversal of neutrophil lymphocyte ratio ; rising haematocrit ; Platelet transfusion.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:16
Last Modified: 22 May 2018 17:47

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