Preethi, M (2015) COX-2 Expression in Endometrial Carcinoma and Its Correlation with Clinicopathological Parameters. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
Endometrial cancer is a common cancer occurring in postmenopausal women. The important prognostic factors include FIGO stage, histologic grade, cell type, myometrial invasion and lymphovascular invasion. The advent of targeted therapy has led to a realm of studies on immunomarkers in various cancers including endometrial cancer. Cyclooxygenase-2 (COX-2) is one among the immunomarkers being studied in endometrial carcinoma. We studied 37 uterine cancers diagnosed on hysterectomy specimens and found that 36 cases (97%) were positive for COX-2 and 29 showed overexpression (78%). Majority of the endometrioid carcinomas (76%) overexpressed COX-2. Overexpression was 100% in all the four non-endometrioid carcinomas, tumors with a nuclear grade of III and tumors presenting in stage II and above. Although the results were close to statistical significance, the observations are noteworthy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Endometrial cancer ; Cyclooxygenase-2 (COX-2) ; overexpression. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Punitha K |
| Date Deposited: | 19 May 2018 15:16 |
| Last Modified: | 22 May 2018 17:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8015 |
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