Correlation of COX-2 Expression in Colorectal Carcinoma with Clinicopathological Features

Manjula, R (2015) Correlation of COX-2 Expression in Colorectal Carcinoma with Clinicopathological Features. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.

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Abstract

INTRODUCTION: Colorectal carcinoma is the most common neoplasm of the gastrointestinal tract. COX-2 (cyclooxygenase-2) expression is upregulated in colorectal carcinoma. Therefore its assessment would identify patients amenable to adjuvant therapy. As no studies have been done across the Indian population as compared to western, the present study was done. AIMS AND OBJECTIVES: To study COX-2 expression in colorectal carcinoma and correlate it with clinicopathological features like age, sex, tumor location, size, degree of differentiation, depth of invasion, lymph node status and TNM stage. METHODS: 65 consecutive cases of colorectal adenocarcinoma between January 2009 to December 2013 were retrived from records of Pathology Department at PSG IMS&R. Immunohistochemical staining for COX-2 was done and correlated with age, sex, tumor location, size, degree of differentiation, depth of invasion, lymph node status and TNM stage. RESULTS: COX-2 was expressed in 86.2% of cases and negative in 13.8%. 90% of left side colonic carcinoma and 77.3% of right colonic carcinoma expressed COX-2. Among the lymph nodes with metastasis, 22.25% were COX-2 negative, 25% low positive and 47.7% were high positive. High positive COX2 cases constituted 33.3% of stage I, 58.8% of stage II, 80% of stage III and 100% of stage IV tumors. About 56.6% of well differentiated, 66.6% of moderately differentiated and 100% of poorly differentiated carcinomas showed high COX-2 expression. The COX-2 overexpression was associated with advancing stage of tumor, more frequent lymph node and distant metastasis, decreasing degree of differentiation. CONCLUSION: Determination of COX-2 expression in colorectal carcinoma gives prognostic information. COX-2 overexpression implicates advancing stage of disease. These patients can be treated with selective COX-2 inhibitors like Celecoxib, Rofecoxib, L-745,337 and SC 58125 as an adjuvant to chemo and radiotherapy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Colorectal carcinoma ; COX2 ; COX2 inhibitor ; Metastasis.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:16
Last Modified: 22 May 2018 17:59
URI: http://repository-tnmgrmu.ac.in/id/eprint/8014

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