Occurrence and Analysis of Cytomorphological Features of Papillary Carcinoma Thyroid in All Other Thyroid Swellings

Jacinth, Babu (2015) Occurrence and Analysis of Cytomorphological Features of Papillary Carcinoma Thyroid in All Other Thyroid Swellings. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.

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Abstract

Papillary Carcinoma is the most malignant tumor among all thyroid cancers. In contrast to its high incidence, death due to papillary carcinoma is rare as they respond well to treatment. Fine Needle Aspiration is the first line diagnostic test for evaluation of any thyroid swelling and papillary carcinoma thyroid can be effectively diagnosed by it. In our study, five cytomorphological features namely: Nuclear grooves, Pseudoinclusions, Papillary fragments, Metaplastic cytoplasm and Three Dimensional fragments were selected and analysed. A quantitative and semi-quantitative assessment was done for the nuclear grooves and intra-nuclear inclusions respectively. Subsequently, Sensitivity and Specificity of each of the above mentioned features was statistically derived. We concluded that presence of ≥ 20% Nuclear grooves with frequent Pseudoinclusions is virtually diagnostic of Papillary carcinoma. The cases which fall in the category of 10-19% nuclear grooves should be considered as Suspicious for malignancy and in cases with < 10% Nuclear grooves, the possibility of Papillary carcinoma can be ruled out.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Papillary carcinoma ; Nuclear grooves ; Pseudoinclusions ; Papillary fragments ; Metaplastic cytoplasm and Three Dimensional fragments ; Thyroid FNA.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:16
Last Modified: 22 May 2018 18:02
URI: http://repository-tnmgrmu.ac.in/id/eprint/8013

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