A Five Year Retrospective Study of Spectrum of Cutaneous Lymphomas presenting to a Tertiary Care Centre

Jigar Kiritkumar, Shah (2015) A Five Year Retrospective Study of Spectrum of Cutaneous Lymphomas presenting to a Tertiary Care Centre. Masters thesis, Christian Medical College, Vellore.

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Abstract

OBJECTIVES: To ascertain frequencies of different cutaneous lymphomas and their correlation with clinical and laboratory parameters as well as to check the role of new markers Notch-1 and Foxp1 in prognostication. METHODS: This 5 year study was carried out in the Department of General Pathology, Christian Medical College and Hospital, Vellore, India. The histopathological materials were accrued from the archives of the department. The clinical information and laboratory parameters were obtained from clinical workstation and charts from medical records department or from the biopsy request forms for outside referral cases. Data entry and statistical analysis were done using Epi-info software. Descriptive statistics such as frequency and percentage were used. Categorical variables were analyzed using χ2 test and Fischer’s exact test. A p value of < 0.05 was considered statistically significant. RESULTS: Totally 115 patients were enrolled in the study with a mean age of 39 years and male predominance. The presenting age was lower than documented earlier, with Mycosis Fungoides (MF) {44%} being the commonest cutaneous lymphoma followed by Subcutaneous panniculitis like T cell lymphoma {21%}. There were increased numbers of hypopigmented MFs (53%), in juvenile cases where females were predominant. The frequency and clinical/laboratory parameters of other T cell lymphomas were comparable to literature. We had increased numbers of cutaneous B cell lymphoma, other type {3.5%}. International Prognostic Index, FoxP1 and Notch-1 were associated with prognosis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Mycosis Fungoides ; Hypopigmented Mycosis Fungoides Notch-1 ; Fox p1.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:16
Last Modified: 22 May 2018 18:05
URI: http://repository-tnmgrmu.ac.in/id/eprint/8006

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