Quantification of Microvessel Density in Breast Carcinomas Based on Immunohistochemistry

Sarangan, A (2015) Quantification of Microvessel Density in Breast Carcinomas Based on Immunohistochemistry. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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Breast cancer is the most frequent neoplasm causing death in women between 35-55 years of age. Angiogenesis is of key importance in the process of tumor progression in a number of tumor types including breast cancer. This is a both retrospective and prospective study which included fifty breast cancer cases. Angiogenesis was estimated by determining micro vessel counting after immune staining the paraffin embedded tissue sections using anti-cd34 antibody. The study is designed to compare MVD in different tumor stage, grade and age group. Age of the patients ranged from 35 to 85 years with a mean age of 52.58 years. Majority showed (40%) more than 84 vessels count in 1 mm2 field area. Micro vascular density positively correlated lymph nodes involved by the tumor and grade of the tumour. In the future, antibodies specific to proliferating endothelium, together with the development of automated image analysis may improve the accuracy and value of measuring angiogenesis-induced microvessel density.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Breast Carcinoma ; Microvessel density (MVD) ; Cd-34 ; Angiogenesis.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:15
Last Modified: 23 May 2018 01:58
URI: http://repository-tnmgrmu.ac.in/id/eprint/8002

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