Evaluation of Expression of Her2/neu in Gastric Cancer and Its Significance as a Prognostic Factor in Gastric Adenocarcinoma

Kavitha, M (2015) Evaluation of Expression of Her2/neu in Gastric Cancer and Its Significance as a Prognostic Factor in Gastric Adenocarcinoma. Masters thesis, Tirunelveli Medical College, Tirunelveli.

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Abstract

Gastric carcinoma is the second common cause of cancer related worldwide deaths. The HER-2/neu is the Human epidermal growth factor receptor-2 and it is a gene localized on chromosome 17q21 that encodes a growth factor receptor like molecule with tyrosine kinase activity and has a structure similar to that of epidermal growth factor receptor. Its expression has been detected in several human cancers and is believed to be associated with poor prognosis, aggressive biological behavior and metastatic potential. The present study is to evaluate the presence of HER-2/neu in gastric cancers of all histological types. IHC is an excellent technique to detect HER-2/neu expression in Gastric carcinoma. Their prevalence in gastric cancer ranges from 9-38% in most studies. This study included 50 cases of gastric carcinoma and these were subjected to immunohistochemical staining for HER-2/neu oncoprotein. Out of 50 cases, only 8 cases of Gastric adenocarcinoma (16%) were found to be positive for HER-2/oncoprotein. In this study Her2 neu expression is more in Oesophageal gastric junctional tumours & corpus location of stomach tumours (35.3%) compared to Pylorus-Antral tumours. And also we observed Her2 neu expression in patients with signet ring cell carcinoma (40%) compared to Non signet ring cell carcinoma.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastric Carcinoma ; IHC ; HER-2/neu.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:15
Last Modified: 23 May 2018 01:52
URI: http://repository-tnmgrmu.ac.in/id/eprint/8000

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