Meningiomas and Hormonal Receptors: An Immunohistochemical Study

Supasakthi, S (2015) Meningiomas and Hormonal Receptors: An Immunohistochemical Study. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND: Meningiomas constitute about 13-26% of primary intracranial tumours. Although most of the meningiomas are benign grade I tumours, they show a recurrence rate of about 30%. Detection of this morphologically benign and biologically aggressive meningiomas cannot be made by routine histology alone. Thus in the present study Progesterone receptor, Estrogen receptor and Ki67 markers were used as an adjuvant approach in the identification of these biologically aggressive meningiomas. OBJECTIVE: To assess the Estrogen receptor, progesterone receptor and Ki67 expression and to compare and to correlate them demographically, histologically and immunohistochemically. MATERIAL AND METHODS: This is a cross sectional study conducted for a period of one year (July 2013-July 2014) in the Department of Pathology, Coimbatore Medical College, Coimbatore. Thirty cases of meningioma were assessed immunohistochemically and correlated with various clinico –pathological parameters. RESULTS: Thirty cases of meningioma were included in the study all of which were grade I tumours. Mean age of all cases were 45 .7 +/- 13.1 years. Females outnumbered males with F: M ratio of 2.7:1. Progesterone receptor positivity seen in about 19 out of 30 cases (63.3%), with none of the cases showing estrogen receptor immunoreactivity. Also PR immunoreactivity was higher in females (68%). Age, location of tumor and subtypes has no correlation with PR. Recurrence was noted in 7 out of 30 cases .The recurrence rate was found to be higher in males (25%). Progesterone expression was higher in Non recurrent tumours (78%). In recurrent tumours, PR expression was decreased (14%) but in contrast Ki67 expression was 100%. There is an inverse relationship between Ki67 and Progesterone receptor expression. Age, Location of tumour and the meningioma subtypes had no role in predicting the recurrence. CONCLUSION: Although meningiomas express progesterone receptor, it is independant of Estrogen receptor, unlike the other hormone dependant tumours like breast and uterus (58). Expression of Progesterone receptor is associated with lesser recurrence and better prognosis. Progesterone receptor can be used along with other histological parameters for prognostication of meningiomas (59,60) Thus, in the grading of meningiomas, histopathological examination alone is not sufficient, ancillary tests with Progesterone receptor and proliferative marker should be included for prognostication of meningiomas.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Meningioma ; Progesterone receptor ; Ki67 ; immunohistochemical study.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:15
Last Modified: 23 May 2018 01:18

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