Priyanka, P (2015) Histomorphology and Role of Immunohistochemistry in Endometrial Carcinomas. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
BACKGROUND: Endometrial carcinoma is the 4th most common among the carcinomas in women, and accounts for 6% of female cancers with 75% cases occurring in postmenopausal women with the peak incidence noted in 55-65 years. Type l tumor occurs in the younger age, arise in the background of hyperplastic endometrium, are of low grade and has a favorable prognosis and show positivity for ER and PR. Whereas Type II carcinomas (serous papillary carcinomas and clear cell carcinomas) occurs in the older age, in the background of atrophic endometrium, show aggressive behaviour and has poor prognosis and are p53 positive. However, some cases of morphologically type I endometrioid carcinomas may express p53 as that of type II carcinomas and this may have a role in the management of the patients. OBJECTIVE: To correlate the clinical features and histopathological features of endometrial carcinoma, to analyze the spectrum of histopathological features of endometrial carcinomas and to correlate the expression of ER, PR and p53 with the histopathological grade of endometrial carcinomas. MATERIAL AND METHODS: This is a cross sectional prospective study conducted during October 2012 - July 2014 in the Department of Pathology, Coimbatore Medical College, Coimbatore. Thirty cases of endometrial carcinomas were examined histomorphologically and correlated immunohistochemically. RESULTS: Thirty cases of endometrial carcinomas were included in the study. The incidence of endometrial carcinomas in our hospital was found to be 1.73%. The expression of ER in type I carcinomas were 81.25% and in type II was 21.43%. It was found that there was a positive correlation between the expression of ER and type I tumor. The expression of PR in type I carcinomas were 75% and in type II 28.75% showed positivity. In the present study, there was a positive correlation between the expression of PR and type I tumor. The expression of p53 in type I carcinomas were 43.75% and in type II 78.57% showed positivity. In the present study there was statistical correlation between the type II endometrial carcinomas and p53 expression. CONCLUSION: The immunohistochemical study of ER, PR and p53 and its significance on the prognosis are few in literature when compared to breast carcinoma. Our data will be definitely an important addition to the existing literature.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Endometrial carcinoma ; immunohistochemistry ; ER ; PR and p53. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Punitha K |
| Date Deposited: | 19 May 2018 15:15 |
| Last Modified: | 23 May 2018 01:20 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7995 |
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