An Assessment of Angiogenesis and Elastosis in Fibrocystic Breast Disease and Invasive Breast Carcinoma

Duraisamy, R (2015) An Assessment of Angiogenesis and Elastosis in Fibrocystic Breast Disease and Invasive Breast Carcinoma. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

BACKGROUND: The tumor progression and metastasis in breast cancer are angiogenesis dependant. Elastosis, the presence of clumps of elastic fibers, is known to occur frequently in association with breast carcinoma. Aim OF THE STUDY: To grade angiogenesis and elastosis in Fibrocystic breast disease and Invasive duct breast carcinoma and correlate them with grade. MATERIAL AND METHODS: 30 cases of fibrocystic breast disease and 30 cases of invasive breast carcinoma were selected and immunohistochemistry with CD34 markers and special stain with verhoff von gieson stain was done for all cases. RESULTS: The severe grade of microvessel density is prognostically significant in Fibrocystic disease with epithelial hyperplasia and Invasive duct breast carcinoma - Nos type cases with high grade (grade III) histological tumors. The significance of grade of elastosis in Fibrocystic breast disease and Invasive ductal breast carcinoma is obscure. CONCLUSION: The microvessel density may have a role as one of the prognostic factors in node negative ductal breast carcinomas.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Fibrocystic breast disease ; Invasive duct breast carcinoma – Nos type Angiogenesis ; Microvessel density grade ; Elastosis grade.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:14
Last Modified: 23 May 2018 01:19
URI: http://repository-tnmgrmu.ac.in/id/eprint/7993

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