Study on etiological and clinical profile of acute symptomatic seizures in adults in a tertiary care hospital.

Amal Raj Iyadurai, E (2014) Study on etiological and clinical profile of acute symptomatic seizures in adults in a tertiary care hospital. Masters thesis, Madurai Medical College, Madurai.

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Abstract

OBJECTIVES: 1. To study the etiological profile of acute symptomatic seizures in various age groups. 2. To assess the common seizure type in patients with acute symptomatic seizures of varied etiologies. 3. To study the Electro Encephalographic and Radiological profile of Acute symptomatic seizures. DESIGN: Single Observational study. This study was conducted among 150 Acute symptomatic seizure patients who were admitted in our hospital with various etiologies since March 2013 to February 2014. RESULTS: In the present study Acute symptomatic seizures were slightly more in males than in females. Acute symptomatic seizures were most common in 40 – 60 years of age group. Generalised seizures were the most common seizure type encountered in the study. Head ache, vomiting and altered sensorium were the most common non convulsive presenting symptoms. Diabetes and Hypertension were the co morbid systemic illness associated with cerebrovascular accidents. Metabolic abnormality was found as the cause in 13% of the patients and the predominant age group was above 60 years. Cerebrovascular diseases were the most frequent etiology in acute symptomatic seizures. Among the cerebrovascular diseases, cortical venous thrombosis and intra cerebral haemorrhage were commonly presented with seizure. Next common cause of acute symptomatic seizures in this study was CNS infections consisting of 19% of the patients. Among CNS infection, Neurocysticercosis was the most common cause. In females eclampsia and cortical venous thrombosis were the common etiology for acute symptomatic seizures. Alcohol related seizures contributed to etiology in 12% of the patients. Hanging and post cardiac arrest were the common etiology the anoxic brain injury. Generalised seizures were common with cerebrovascular disease and alcohol related seizures. Partial seizures were common with Tuberculoma and Neurocysticercosis. Myoclonic seizures were common with anoxic brain injury. Cerebrovascular disease and Metabolic abnormality were common above 60 years where as eclampsia and alcohol related seizures were common in 20 – 60 years of age. Acute CNS infection was the predominant cause of seizures below 20 years of age. Conclusion: Acute symptomatic seizures were more common in males than females and in 40 – 60 years of age. Cerebrovascular diseases were the most frequent cause of acute symptomatic seizures, followed by Acute CNS infections. Eclampsia and cortical venous thrombosis were the common etiology among females. Cerebrovascular diseases and metabolic abnormality were common above 60 years of age where as eclampsia and alcohol related seizures were common in 20-60 years of age. Acute CNS infections were the predominant cause of acute symptomatic seizures below 20 years of age. Generalised seizures were the most common seizure type encountered in this study. EEG and Radiological abnormalities were seen in nearly 60% of the patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Study on etiological and clinical profile; GTCS, CVT, SDH, SAH, Acute symptomatic seizures ; adults ; tertiary care hospital.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 03 Jul 2017 08:28
Last Modified: 03 Jul 2017 08:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/799

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