A Study on FNAC and Biopsy Correlation of Thyroid Lesions - Immunohistochemistry of Thyroid Malignancy

Revathy, M (2015) A Study on FNAC and Biopsy Correlation of Thyroid Lesions - Immunohistochemistry of Thyroid Malignancy. Masters thesis, Kilpauk Medical College, Chennai.


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Thyroid lesions are common in surgical practice with incidence of 4-7% of the population82. The incidence of thyroid malignancy is 1% with papillary carcinoma of thyroid being the most common comprising about 84% of thyroid malignancies. The salient features observed in the study were: 1. Thyroid lesions constitute about 12.98% of head and neck lesions. 2. Thyroid tumours constitute about 1.36% of head & neck lesions. 3. The incidence of papillary carcinoma of thyroid is 10.5% 4. The common age group affected was 30-39yrs. 5. The median age of presentation of papillary carcinoma thyroid was 39yrs. 6. Females were commonly affected with male female ratio of about 1:10.1. 7. 74% of thyroid FNAC had positive correlation with histopathology. 8. Non neoplastic lesions were more common than neoplastic lesions in thyroid with a incidence of 86%. 9. Nodular goiter was more common among non neoplastic lesions in both cytology and histopathology with a incidence of 76% and 61% respectively. 10. Follicular adenoma was the most common neoplastic lesion in both cytology and histopathology with a incidence of 9% and 13% respectively. 11. The sensitivity, specificity and diagnostic accuracy of FNAC in detecting neoplastic and non neoplastic lesions was 82%, 78% and 97% respectively. 12. The sensitivity, specificity and accuracy of FNAC for detecting papillary carcinoma of thyroid was 100%,91.98% and 92.31%. 13. Ki-67 staining was seen in 52.38% in PTC, 68.75% in follicular adenoma, 62.5% in nodular goiter. 14. p53 staining was seen in 47.62% in PTC, 75% in follicular adenoma and 50% in nodular goiter. Both these markers were statistically significant in differentiating non neoplastic and neoplastic lesions. CONCLUSION: In conclusion, FNAC is a safe, simple, rapid, cost effective and accurate method in diagnosing thyroid lesions with high sensitivity, specificity and efficacy. It can be used as an initial investigation in the management of thyroid diseases and avoid unnecessary surgery.

Item Type: Thesis (Masters)
Uncontrolled Keywords: fine needle aspiration cytology (FNAC) ; Biopsy Correlation ; Thyroid Lesions ; Immunohistochemistry ; Thyroid Malignancy.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:14
Last Modified: 22 May 2018 18:54
URI: http://repository-tnmgrmu.ac.in/id/eprint/7989

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