A Comparative Study of International Classification for Lung Cancer and WHO Classification in Histological Diagnosis of Lung Cancer in Small Biopsies

Nithya, I (2015) A Comparative Study of International Classification for Lung Cancer and WHO Classification in Histological Diagnosis of Lung Cancer in Small Biopsies. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND : Lung cancer is a highly aggressive malignancy causing high morbidity and mortality. An increasing incidence of lung cancer has been observed in India. Currently, the classification of lung carcinoma has gone beyond small cell lung carcinoma and non‑small cell lung carcinoma (NSCLC). Precise subtyping of poorly differentiated NSCLC into adenocarcinoma and squamous cell carcinoma has a direct impact on patient management and prognosis.70% of lung cancers are unresectable, as patients present in advanced stages. Hence small biopsy and cytology specimens are the primary method of diagnosis for the majority of lung cancers.Also, prior 2004WHO classifications primarily addressed resection specimens, they did not propose standardized terminology and criteria for small biopsies and cytology. Hence this new 2011 IASLC classification provides for the first time a proposed set of terms and criteria for all major histologic types of lung cancer in small biopsies and cytology. AIMS AND OBJECTIVES: To classify lung cancer according to International classification based on morphology, special stains and IHC in small biopsies and compare the same with previous WHO classification. And finally to determine the diagnostic supremacy of one classification over the other and its therapeutic implications. MATERIALS AND METHODS: 151 cases Paraffin sections of small biopsy samples diagnosed as Non small cell lung carcioma will be subjected to routine H&E staining and supplemented to special stain for mucin (alcian blue/PAS) and IHC markers p40(marker of SCC) and TTF1(marker of adenocarcinoma). RESULTS: Of the total 151 cases studied on morphological basis, 121 Cases were diagnosed as adenocarcinoma and squamous cell carcinoma. The remaining 30 cases diagnosed as NSCLC-NOS. In this study, According to IASLC/ATS/ERS, the percentage of NSCLC – NOS was minimised with the use of alcian blue/PAS and the IHC markers p40 and TTF 1, from 19.86% to 1.86% CONCLUSION: According to this study we conclude that multidisciplinary International Classification For Lung Cancer is superior to 2004 WHO classification in terms of diagnostic, therapeutic and prognostic implications.

Item Type: Thesis (Masters)
Uncontrolled Keywords: International Classification for Lung Cancer ; WHO Classification ; Histological Diagnosis ; Lung Cancer ; Small Biopsies ; Comparative study.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:13
Last Modified: 22 May 2018 19:19
URI: http://repository-tnmgrmu.ac.in/id/eprint/7981

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