Comparison of Stromal CD10 Expression in Benign, Borderline and Malignant Phyllodes Tumors

Hemavathi, M (2015) Comparison of Stromal CD10 Expression in Benign, Borderline and Malignant Phyllodes Tumors. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: Phyllodes tumor is a rare fibroepithelial tumor of the breast comprising less than 1% of all primary breast tumor. Phyllodes tumors are graded into benign, borderline and malignant based on histological criteria. Grading of phyllodes tumor is important as it determines the biological behaviour of the tumor. AIM OF THE STUDY: The aim of the present study was to identify the incidence and clinicopathological features of benign, borderline and malignant phyllodes tumors and to compare the CD10 expression in benign, borderline and malignant phyllodes, in order to highlight its diagnostic significance. MATERIALS AND METHOD: The clinical and pathological findings of phyllodes tumors were retrieved from the surgical pathology records from January 2012 to June 2014.Totally 50 case were selected randomly (38 benign, 6 borderline and 6 malignant) and their representative formalin fixed paraffin embedded tissue samples were subjected to immunohistochemistry for CD10 expression. RESULTS: In the 38 cases of benign phyllodes tumors, only three cases (7.9%) were CD10 positive. Three out of six cases (50%) of borderline phyllodes tumors showed CD10 positivity, whereas five out of six cases (83.3%) of malignant phyllodes tumor showed CD10 positivity. CONCLUSION: CD10 expression correlated well with grade of phyllodes tumors, which is of statistical significance and therefore it can be used in the determination of tumor grade and this may pave way for development of targeted therapies.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Stromal CD10 Expression ; Benign ; Borderline ; Malignant Phyllodes Tumors ; Comparison study.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:13
Last Modified: 22 May 2018 19:06

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