Karyotyping in Chronic Myeloid Leukemia

Devipangaj, S (2015) Karyotyping in Chronic Myeloid Leukemia. Masters thesis, Madras Medical College, Chennai.

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Abstract

The prognostic relevance of additional cytogenetic findings at diagnosis of Chronic Myeloid Leukemia (CML) is unclear. The impact of additional cytogenetic findings at diagnosis on time to progression free survival and clinical and laboratory features along with disease course is analysed in 30 cases of Chronic Myeloid Leukemia and compared with patients presenting with standard t (9,22) (q34, q11.2) only karyotype. 6 cases (20%) were found to have abnormal karyotype at diagnosis, of which 4 (13.33%) were additional chromosomal abnormality (ACA), 1 patient (3.33%) had complex variant karyotype and 1 patient (3.33%) had –Y. On median observation for 15 months, the patients with ACA were found to have accelelaration of disease, abnormally high counts, renal compromise and unexplained thrombocytopenia and this indeed signifies the importance of cytogenetic diagnosis at initial diagnostic workup and the impact they have on progression of disease and prognosis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Karyotyping ; Chronic Myeloid Leukemia.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 19 May 2018 15:12
Last Modified: 22 May 2018 17:38
URI: http://repository-tnmgrmu.ac.in/id/eprint/7977

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