Prevalence of asymptomatic cardiac and renal damage in treatment naïve adult patients with Systemic Hypertension and its co-relation with hsCRP and Uric acid levels: A Cross Sectional Study

Muthukumaran, P (2015) Prevalence of asymptomatic cardiac and renal damage in treatment naïve adult patients with Systemic Hypertension and its co-relation with hsCRP and Uric acid levels: A Cross Sectional Study. Masters thesis, Christian Medical College, Vellore.

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Abstract

OBJECTIVES: To look at the prevalence of asymptomatic cardiac and renal damage in newly diagnosed treatment naive adult patients with systemic hypertension and to study the co-relation between inflammatory markers, hsCRP and uric acid, with the asymptomatic organ damage in hypertensives. METHODS: The study recruited 98 hypertensives who presented to the medicine OPD and were willing to participate in the study. The patient data was collected with a questionnaire and the blood pressure, height, weight and abdominal circumference were measured in these patients. The blood investigations including fasting glucose, creatinine, electrolytes and lipid profile were done in these patients. The patients also underwent electrocardiography and echocardiography with the documentation of M-Mode values. The albumin creatinine ratio, eGFR and the LV Mass index were also subsequently calculated in these patients. RESULTS: The prevalence of microalbuminuria was 31.9% and the prevalence of Left ventricular Hypertrophy was 29.59% of the study population. The uric and hsCRP were not related to asymptomatic organ damage when analysed. The hsCRP was however very significantly related to body mass index (p=0.000) and abdominal circumference (p=0.003) on bivariate analysis. This association of hsCRP to elevated body mass index and abdominal circumference might be due to its association with the metabolic syndrome. CONCLUSION: Almost one third of the newly detected hypertensives in the study population had evidence of asymptomatic cardiac and renal damage. However, the asymptomatic cardiac and renal damage was not related to elevated inflammatory markers in these patients. The elevated hsCRP in the study population might berelated to an underlying metabolic syndrome.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Keywords Microalbuminuria ; LV Mass Index ; Asymptomatic organ damage ; newly detected hypertension ; prevalence of asymptomatic organ damage.
Subjects: MEDICAL > General Medicine
Depositing User: Punitha K
Date Deposited: 18 May 2018 18:57
Last Modified: 18 May 2018 18:57
URI: http://repository-tnmgrmu.ac.in/id/eprint/7962

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