Priya, Sreeraj (2015) Correlation of Serum Immunoglobulin E Levels and Absolute Eosinophil Counts in assessing Severity of Bronchial Asthma as assessed by Lung Spirometry. Masters thesis, Coimbatore Medical Collegel, Coimbatore.
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Abstract
BACKGROUND: In our country, there is a huge burden due to asthma and a huge proportion of these cases are left underrecognised, underestimated and undertreated. Asthma is now considered a single airway disease and hence comprehensive diagnosis, treatment and follow up is essential. Majority of asthma patients are atopic according to population studies. The prevalence of asthma increases with increasing severity of asthma according to population studies. In asthma patients eosinophils are present in blood, sputum, bronchial lavage. Further studies are required to prove its association with severity of asthma AIMS AND OBJECTIVES: 1. To establish an association between airway inflammation as assessed by absolute eosinophil count and disease severity. 2. To establish an association between atopy as demonstrated by serum Immunoglobulin E levels and disease severity. 3. To correlate the clinical presentation, Serum IgE and absolute eosinophil count with severity of bronchial asthma as assessed by lung spirometry. 4. To predict the prognosis and treatment outcome of bronchial asthma patients from absolute eosinophil count and serum Ig E levels. METHODOLOGY: 100 patients who were diagnosed to have bronchial asthma in Coimbatore Medical College hospital were included in the study population. Risk factors, family history and other associated comorbid conditions were recorded .Severity was assessed by doing lung spirometry in all patients. Serum immunoglobulin E and absolute eosinophil count was done in patients for those classified into mild, moderate and severe groups. Correlation was assessed between each of these variables and severity. RESULTS: Positive correlation was found between asthma severity and absolute eosinophil count in the severe persistent asthma group which was statistically significant. Serum Ig E levels correlate with asthma severity and the mean Ig E in mild was 271.50 IU/mL, moderate group was 916.48 IU/mL and severe group was 1662.59 IU/mL. CONCLUSION: Serum immunoglobulin E and absolute eosinophil counts were found to have positive correlation with asthma severity. Estimation of these parameters can be used as simple tools in assessing asthma severity based on clinical grading.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Bronchial asthma ; Absolute Eosinophil Count ; Serum immunoglobulin E. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:56 |
| Last Modified: | 22 May 2018 17:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7940 |
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