Ramya, A (2015) Study on Association between Serum Bilirubin and Acute Ischemic Stroke and Its Prognostic Significance. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
BACKGROUND: Bilirubin as a marker of oxidative stress can be increased in acute ischemic stroke. OBJECTIVE: To find any association exists between serum bilirubin level and acute ischemic stroke and assess the usefulness of serum bilirubin in determining the severity and prognosis of stroke. METHODS AND MATERIALS: Bilirubin and other biochemical parameters were measured in 50 cases (acute ischemic stroke) and 50 age, sex, comorbid conditions matched controls. NIHSS score was assessed at admission and MRS score was assessed after 7days of stroke. Serum total bilirubin levels were divided into 3 groups <0.6mg/dL,0.7-0.9mg/dL,≥1.0mg/dL. NIHSS score was divided into two groups ≥10 (Severe Stroke) and <10. MRS score was divided into two groups <3 (Good Outcome) and ≥3 (Poor Outcome). The bilirubin level and its association with acute ischemic stroke and its correlation with stroke severity and prognosis was analyzed. RESULTS: The level of serum total bilirubin and indirect bilirubin was significantly higher in acute ischemic stroke patients (p value < 0.001 and <0.001 respectively) than in the control group. The level of serum direct bilirubin didn’t show any significant correlation. The level of serum total bilirubin (p value 0.0003 and 0.0002 respectively) and indirect bilirubin (p value 0.003 and 0.001 respectively) was significantly correlated with NIHSS ≥ 10and MRS ≥ 3. CONCLUSION: In this study it was found that serum levels of total and indirect bilirubin were increased after acute ischemic stroke. Both serum total bilirubin and indirect bilirubin can reflect the severity and prognosis of stroke.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Bilirubin ; Acute Ischemic Stroke ; Severity ; Prognosis |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:54 |
| Last Modified: | 19 May 2018 02:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7905 |
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