Harikrishnan, J (2015) Association of Serum Uric Acid Levels in Acute Ischemic Stroke. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
BACKGROUND: For decades the role of Uric acid as a independent risk factor for noncommunicable disease is a subject of discussion. Serum Uric acid is a powerful antioxidant that scavenge many harmful free radicals like hydroxyl ions, peroxinitrite along with other anti-oxidants like ascorbic acid .But elevated serum uric acid can act as pro-oxidant that cause various inflammatory reactions. Serum uric acid can cause endothelial dysfunction, nitric oxide reduction in cells, platelet dysfunction, vascular smooth muscle cells proliferation and activates RAAS. AIM OF THE STUDY: 1. To study the association between serum uric acid level and acute ischemic stroke. 2. To study the association between serum uric acid level and other risk factors like SHT, DM, CAD, Obesity. METHODS: This is an analytical cross sectional study done at Govt. Royapettah Hospital. Serum uric acid levels were measured within 24hrs of onset of scute ischemic stroke. 50 patients were studied. Serum uric acid level was taken as 6.5mg/dl. This value was compared with various other variables. RESULTS: Of the study population 66% were male and 34% were female. 38% of the population were <60yrs ad 62% were>60 yrs of age. 76% were hemiparetic and 24% were hemiplegic. 76% had serum uric acid <6.5mg/dl and 24% had serum uric acid levels >6.5mg/dl. The study revealed the strong association between the serum uric acid and DM, SHT, CAD, Dyslipidemia with a p value <0.05. The study also revealed that the association of uric acid with age and smoking was insignificant with p value >0.05. All patients admitted with hemiplegia have serum uric level >7mg/dl which is highly significant. CONCLUSION: The study shows that uric acid levels may be considered as an independent predictor for ischemic stroke. SUA has a strong association with DM, SHT and CAD.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Association ; Serum Uric Acid Levels ; Acute Ischemic Stroke. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:53 |
| Last Modified: | 19 May 2018 01:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7900 |
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