Dyslipidemia in Treatment Naïve HIV

Sivakumar, R (2015) Dyslipidemia in Treatment Naïve HIV. Masters thesis, Madurai Medical College, Madurai.


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INTRODUCTION: The natural history of human immunodeficiency virus (HIV) infection changes with the use of highly active antiretroviral therapy (HAART) through reduction in risks of death associated with the condition and improvement of the quality of life of people living with the infection. Abnormalities of lipid metabolism are common in HIV infected patients and tend to be accentuated in those receiving highly active antiretroviral therapy (HAART). The study was conducted to describe the pattern of lipid profile among treatment naïve-HIV positive patients. AIMS AND OBJECTIVES: To study the derangement of lipid profile in treatment naïve HIV. METHODS: Data were collected from 100 normotensive, non-diabetic and non-obese treatment and 100 age and sex matched healthy controls. The study was carried out at ART center in Govt. Rajaji Hospital, Madurai from December 2013 to July 2014. RESULTS: The study observed a significant increased level of triglycerides and low density lipoprotein cholesterol and a significant decreased level of total cholesterol and high density lipoprotein cholesterol. CONCLUSION: HIV-I replication alone without any influence of human genetic factors and antiviral drugs induces changes in serum lipid profile which could be used to determine HIV-infected persons with high risk of Myocardial infarction before enrollment for HAART.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Dyslipidemia ; Treatment-Naïve ; HIV.
Subjects: MEDICAL > General Medicine
Depositing User: Punitha K
Date Deposited: 18 May 2018 18:53
Last Modified: 18 May 2018 18:53
URI: http://repository-tnmgrmu.ac.in/id/eprint/7893

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