Serum Apolipoprotein A-1 Levels in Pregnancies with Intrauterine Growth Restriction.

Uma, Unnikrishnan (2006) Serum Apolipoprotein A-1 Levels in Pregnancies with Intrauterine Growth Restriction. Masters thesis, Madras Medical College, Chennai.


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Hyperlipidemia is commonly found in normal population associated With pathologies such as hypertension and atherosclerosis. In pregnant women However, hyperlipidemia has serious implications. The increased nutritional Requirement of the fetoplacental unit and the endocrine profile during Pregnancy could explain the biochemical changes in lipid metabolism of Pregnancy. The major lipids of human body are phospholipids, cholesterol, Triglycerides and cholesteryl esters. These insoluble lipids are transported Through blood as lipoproteins consisting of lipids and one or more specific Proteins called apolipoproteins. In pregnancy, increase in female sex hormones, And lipolysis due to placental lactogen, cause an increase in lipid synthesis and Metabolism resulting in increased cholesterol, triglycerides and phospholipid Concentrations. Ideally, sufficient maternal nutrients provided across uteroplacental Circulation function efficiently to meet the demands of the growing fetus. If Balanced interaction between mother and fetus is disturbed it leads to Intrauterine Growth Restriction (IUGR) which is associated with higher Perinatal mortality and morbidity. Growth restricted fetuses are those born with Birth weight 2500g or less. More studies on biochemical changes in pregnancy are necessary to Characterise the excessive gestational lipolytic responses. This would enable us To determine if the changes in lipoprotein profile during pregnancy imply a Greater atherogenic risk with possible repercussions on fetal growth and Development. Haemorrheological modifications in growth restricted Pregnancies are partly secondary to changes in high density lipoprotein Metabolism. Changes in apolipoprotein A-1 could be a good marker for the Early detection of intrauterine growth restricted pregnancies. In this study, the lipid fractions and apolipoprotein A-1 in normal Pregnancies and pregnancies with intrauterine growth restriction were Determined and compared.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Serum Apolipoprotein A-1 Levels ; Pregnancies ; Intrauterine Growth Restriction.
Subjects: MEDICAL > Biochemistry
Depositing User: Subramani R
Date Deposited: 03 Jul 2017 11:57
Last Modified: 03 Jul 2017 11:57

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