Chinna Mariappan, G (2015) Study of Cardiac Abnormalities in HIV Patients and their Correlation with CD4 Count. Masters thesis, Madurai Medical College, Madurai.
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Abstract
INTRODUCTION: Human immunodeficiency virus is a retrovirus that affects all systems in the body. Among this cardiovascular disease is one of the leading causes of non HIV related death in HIV patients. Although many cardiovascular complications have been described like pulmonary hypertension, systemic hypertension, infective endocarditis and accelerated atherosclerosis in HIV patients, the most common complications include diastolic dysfunction, left ventricular systolic dysfunction, pericardial effusion, dilated cardiomyopathy and coronary artery disease. As the disease progresses the CD4 count declines which increases the cardiovascular complications leading to death. So echocardiographic screening should be performed in all HIV patients with low CD4 count for early detection and management of the complications. AIMS AND OBJECTIVES 1. To assess the cardiac abnormalities such as systlolic dysfunction, diastolic dysfunction, dilated cardiomyopathy, coronary artery disease, pulmonary hypertension and infective endocarditis and their correlation with CD4 count. 2. To evaluate whether this parameter can be used as prognostic marker of disease progression in HIV patients. MATERIALS AND METHODS: Study Population: This study was conducted among 200 HIV positive patients coming to ART Centre, Govt. Rajaji Hospital, Madurai. Study Protocol: Cases were classified as HIV patients into four groups depending upon the CD4 cell count >500 ( stage1),CD4 cell count 200 – 500 (stage 2), and 50-200(stage 3) and <50 (stage 4). CD4 count, ECG and Echocardiograrm were done in all the participants of the study. RESULTS: In this study pericardial effusion was the most common finding and was present in 15% of the study population, followed by systolic dysfunction (13%),diastolic dysfunction (11.5%) and dilated cardiomyopathy (9%) and all were statistically significant. All cardiac abnormalities were present in patients in stage 3&4 with low CD4 count (<200/microlitre). CONCLUSION: Cardiovascular abnormalities are more common and predictable complications in late stages of HIV infection. So all HIV patients with low CD4 count (<200/microlitre) should be screened for cardiac abnormalities. Early diagnosis and management of these complications is associated with increased survival rates and clinical outcomes in HIV patients.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Cardiac Abnormalities ; HIV Patients ; Correlation ; CD4 Count. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:52 |
| Last Modified: | 18 May 2018 18:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7878 |
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