Akila, S (2015) Comparitive Study of Lipoprotein (a) Level in Type 2 Diabetics and Non Diabetics with Acute Coronary Syndrome. Masters thesis, Madurai Medical College, Madurai.
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Abstract
AIM AND OBJECTIVES: 1. To compare the level of lipoprotein (a) level in type 2 diabetics and non diabetics in association with acute coronary syndrome. 2. To assess whether lipoprotein (a) level is increased in type 2 diabetics when compared to non diabetics. METHODOLOGY: Fifty type 2 diabetic patients and fifty non diabetic patients admitted with acute coronary syndrome were selected after matching forage and sex, during the study period between july 2014 to September 2014. Lipoprotein(a)was studied in these patients. SOURCE OF DATA: Patients admitted with acute coronary syndrome in cardiac ICU, government Rajaji Madurai medical college, Madurai, during the study period of July 2014 to September 2014. Sample Size: 100 cases. Duration Of Study: July 2014 to September 2014. Inclusion Criteria: Patients with angina, occurring at rest (CCS class IV) of duration more than 30 minutes, but within 24 hours from onset of angina were included in the study. Among them, fifty patients had type 2 diabetes. Fifty age and sex matched non diabetic were included as the other group. Diabetes was ruled out in non diabetic group with fasting and 2-hr post prandial blood glucose measurement. Exclusion Criteria: 1. Severe hypothyroidism, 2. Treatment history of taking oral contraceptive pills, 3. Type1 diabetes, 4. Renal failure. CONCLUSION: Type-2 diabetic patients have higher level of Lp(a) level during acute coronary syndrome when compared to non diabetic group. So, the type-2 diabetic patients have nearly 2 fold risk of having high Lp(a) level than non diabetic group. Elevated Lp(a) in type -2 diabetic patients contribute to the accelerated atherogenic / prothrombotic state, causing major adverse cardiac events. SUMMARY: 1. Serum Lp(a) level is high in type -2 diabetic patients with acute coronary syndrome when compared to non diabetic patients. 2. Mean serum Lp(a) in present study was 27.62±12.8mg/dl. The value of Lp(a) varies from 7mg/dl to 60mg/dl. 3. Triglycerides, total cholesterol and LDL were significantly higher in patients with type -2 diabetics and acute coronary syndrome compared to non diabetic patients. 4. HDL cholesterol levels were significantly lower in patients with type - 2 diabetic patients when compared to non diabetic group with acute coronary syndrome.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Lipoprotein (A) ; Lipid Profile ; Type 2 Diabetics ; Non Diabetics ; Acute Coronary Syndrome. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:51 |
| Last Modified: | 22 Dec 2018 14:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7876 |
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