A study of clinical profile and treatment outcome of central nervous system Tuberculosis.

Sankara Narayanan, P (2010) A study of clinical profile and treatment outcome of central nervous system Tuberculosis. Masters thesis, Madurai Medical College, Madurai.

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INTRODUCTION: The Atharvana veda calls it another name “balasa”. It is in the Atharvana veda that the first description of scrofula is given “Tuberculosis of the Central Nervous system” is of great clinical importance. Once a disease mainly of childhood, it is now seen at any age and is equally frequent in adults. The pattern of Tuberculosis infection of the Nervous system is changing (Kocens and Parsons, 1970). Since the prognosis for life and freedom from disability depends more than any other factors on the stage at which treatment begins, early recognition is all important.1 Yet unfortunately diagnosis is often delayed, sometimes because patients are not brought for attention until the condition is far advanced and sometimes because tuberculosis is not suspected by Physicians. AIM OF THE STUDY: 1. To analyse the various clinical presentations of Central Nervous System Tuberculosis, 2. To analyse the complications, morbidity and mortality of Central Nervous System Tuberculosis and 3. To study the treatment outcome of Central Nervous System Tuberculosis. CONCLUSIONS; 1. The most common type of Central Nervous System Tuberculosis was tuberculous meningitis. 2. The comorbid factors associated with Central Nervous System Tuberculosis were malnutrition, smoking, alcoholism, tobacco chewing, diabetes mellitus, and head trauma. 3. The severity of the symptoms present at the time of admission had direct relationship with worsening of the disease. 4. Hydrocephalus was the most common sequelae of Central Nervous System Tuberculosis. 5. Prognosis was better in patients in whom diagnosis and treatment was done earlier. 6. Patient with more than one type of CNS tuberculosis had grave prognosis. 7. Prognosis of tuberculoma depended on the site, number of the tuberculomas and the presence of raised intracranial tension. 8. Early use of steroids along with antitubercular treatment improved the outcome of disease. 9. MRI and CT scan had important role in follow up of the disease.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Central nervous system ; Tuberculosis ; treatment outcome ; clinical profile.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 03 Jul 2017 08:24
Last Modified: 03 Jul 2017 08:24
URI: http://repository-tnmgrmu.ac.in/id/eprint/787

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