Mohammed Omar Farooq, B (2011) An In Vitro Evaluation of the Antibacterial Efficacy and Mechanical Properties of Glass Ionomer Cement - Fuji IX Incorporated with Three Antibiotics. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
This study evaluated the antibacterial effect; physical properties and bonding strength of conventional glass ionomer cement containing antibiotic mixture. The three antibiotic mixture used in this study were Metronidazole, Ciprofloxacin and Minocycline. They are mixed with the glass ionomer cement powder to obtain concentration ratios of 0.75%w/w, 1.5% w/w and 3.0% w/w respectively. The antibacterial activity of each cement ratio was evaluated against Streptococcus mutans and Lactobacillus casei using agar diffusion test. The antibiotic drug release from drug mixture was analyzed at the end of 24 hrs and 7 days by High Performance Liquid Chromatography (HPLC). The Compressive strength at the end of 24 hrs and 7days and the Bond strength was measured and compared with the control group using Instron Universal Testing Machine. Statistical analysis was made by analysis of variance (ANOVA) followed by Duncan’s multiple range test (DMRT). The experimental groups showed significantly greater inhibition zones in comparison with the control group. The bacterial inhibition zone for both the selected bacteria for the groups 1.5%w/w and 3.0%w/w were almost the same in set an unset speciments. Drugs released from the drug mixture also showed increased drug release with increase in concentration. 0.75%w/w and 1.5%w/w showed sustained release at the end of 24hrs and 7 days. Whereas 3.0%w/w a drop in release was observed at the end of 7 days. At 3.0%w/w the properties of the glass ionomer cement was compromised. The compressive strength was less for 3.0%w/w when compared to the control group, 0.75% and 1.5% groups at the end of 24 hrs and 7 days. Altering the composition of the glass ionomer cements also results in change in their Bond strength. At a high concentration of 3.0%w/w showed the bond strength was decreased when compared with the control group and 0.75% w/w and 1.5% w/w at the end of 24 hrs. Therefore addition of 0.75% w/w antibiotic mixture was optimal in achieving effective antibacterial properties, sustained drug release and to have an appropriate physical properties and bonding strength. CONCLUSION: The results of this In vitro study confirmed the following findings and substantiated few past findings: 1. Glass ionomer containing antibiotic mixture have added advantage of being more effective in inhibiting bacteria associated with dental caries than pure glass ionomer. 2. There was a sustained amount of drug released observed both at the end of 24hrs and 7 days, for all the groups. 3. The antibiotic mixture at a concentration ratio of 0.75% w/w resulted in achieving favorable physical properties like better.compressive strength at the end of 7 days, and bonding strength. However, the long – term pharmacological and clinical effectiveness of Glass Ionomer Cement containing Antibiotics should be investigated in future studies.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Antibacterial Efficacy ; Mechanical Properties ; Glass Ionomer Cement ; Fuji IX Incorporated ; Three Antibiotics. |
| Subjects: | DENTAL > Conservative Dentistry and Endodontics |
| Depositing User: | Kambaraman B |
| Date Deposited: | 14 May 2018 03:49 |
| Last Modified: | 14 May 2018 03:49 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7814 |
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