Comparative Analysis of Clinical and Radiological Parameters of Intrabony Defects treated with Autogenous Bone Grafts and Xenograft combined with PRP: A Six months Follow Up Study

Arthiie, T (2011) Comparative Analysis of Clinical and Radiological Parameters of Intrabony Defects treated with Autogenous Bone Grafts and Xenograft combined with PRP: A Six months Follow Up Study. Masters thesis, J.K.K. Nataraja Dental College, Komarapalayam.

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Abstract

The present study involved a comparative clinical and radiographic evaluation of regenerative osseous surgery performed with autogenous bone grafts and demineralized xenograft (osseograft) combined with PRP. The study population comprised of 7 patients age ranging from 20-50 years. All patients returned for scheduled maintenance visits. A total of 14 intrabony defects were treated and post operative healing in the grafted areas was satisfactory. The following clinical parameters like plaque index, gingival index, oral hygiene index (simplified), probing pocket depth and clinical attachment levels were assessed at baseline, 3 months and 6 months. Hard tissue evaluation was done to measure the amount of bone fill in the grafted sites using Auto-CAD 2006 software. Within the framework of this study, the following conclusions have been elucidated:- 1. Both Autogenous bone graft and combination of Demineralized Bovine derived Xenograft (Osseograft) with PRP, used as regenerative graft material in bone grafting yielded favorable clinical results in periodontal intrabony defects. 2. Probing pocket depth and gain in attachment level were significant in both Groups compared to their pre-operative levels. 3. Both the Groups exhibited significant amount of bone fill following therapy. But sites grafted with autogenous bone grafts (Group 1) showed a statistically highly significant (p<0.001) amount of bone fill indicative of better graft remodeling compared to sites grafted with mixture of xenograft and PRP (Group 2) at 3rd and 6th months post operatively. 4. Thus when mean scores were compared between Groups at 3rd and 6th months post- operatively, there was statistically highly significant difference (p<0.001) in Group 1 as far as clinical parameters and radiographic measurements were concerned. The results presented here clearly demonstrate that the autogenous bone graft and combination of bovine derived xenograft (Osseograft) with PRP has the potential to promote predictable periodontal regeneration in the treatment of periodontal intraosseous defects. The results also indicate that surgical reconstructive treatment of intra-osseous defects with autogenous bone graft (Group 1) resulted in clinically and statistically significant higher probing pocket depth reduction, clinical attachment level gain and radiographic bone fill compared to xenograft mixed with PRP (Group 2). However, it is necessary to have a large sample size and long term well controlled clinical trails to evaluate the true efficacy of these materials. Also further studies needed to be carried out to confirm the effects of PRP in periodontal regeneration.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinical and Radiological Parameters ; Intrabony Defects treatment ; Autogenous Bone Grafts ; Xenograft ; PRP ; Six months Follow Up study.
Subjects: DENTAL > Periodontology
Depositing User: Kambaraman B
Date Deposited: 13 May 2018 04:35
Last Modified: 13 May 2018 04:35
URI: http://repository-tnmgrmu.ac.in/id/eprint/7758

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