Ramesh, P (2011) Evaluation of Platelet Activation by estimating Serum sP-Selectin Level and Morphological Changes of Platelets in Periodontal Health and Disease. Masters thesis, Tamilnadu Government Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: The association of periodontitis and cardiovascular diseases is a long standing dilemma and the underlying mechanism between these two diseases is not clear. Regular transient bacteremia occurs during tooth brushing and mastication in periodontitis patients, which provoke the synthesis of proinflammatory mediators in systemic circulation leading to systemic inflammation and platelet activation. Consequently coagulation cascade activation leads to atherothrombosis and CVD. AIM OF THE STUDY: This study is aimed to investigate whether periodontitis patients have higher platelet activation compared to controls. MATERIALS AND METHODS: About 80 subjects were included and categorized into control group (n=40) and study group (n=40). This study comprises of a qualitative and a quantitative analysis. In qualitative analysis change in shape and aggregation pattern of platelets were assessed by spreading analysis test using light microscopy and serum Sp-selectin level is estimated quantitatively by ELISA method. RESULTS: In present study patients with periodontitis showed significantly higher number of activated platelets and pathological aggregation pattern with elevated serum sP-selectin level when compared to controls and is positively correlated with the disease severity. CONCLUSION: Platelet activation is associated with periodontitis and it is severity dependent. Chronic persistent low grade systemic inflammation due to periodontitis may contribute to cardiovascular disease development and progression. Chronic periodontitis could be a possible risk factor for cardiovascular and cerebro-vascular diseases.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Platelet Activation ; Serum sP-Selectin Level ;Morphological Changes of Platelets ; Periodontal Health and Disease. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 13 May 2018 03:59 |
| Last Modified: | 13 May 2018 03:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7755 |
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