Mannam, Ashok Kumar (2014) Formulation and Evaluation of Levetiracetam Niosomes for Improved Anti-Convulsant Activity. Masters thesis, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India.
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Abstract
Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether and cholesterol with subsequent hydration in aqueous media in Niosomes, the vesicles forming amphiphile is a non-ionic surfactant such as span-60 which is usually stabilised by addition of cholesterol and small amount of anionic surfactant such as dicetyl phosphate. Levetiracetam niosomal formulation was prepared by hand shaking method and it was evaluated for its entrapment efficiency, in-vitro drug diffusion profile, sterility tests and stability studies. The optimized formulation F2 and levetiracetam plain were evaluated for it’s anti-convulsant activity using flexion, extension, convulsion, stupor, recovery and death. The effects produced by the formulation (F2) in the mice were comparable with that of the in-vitro drug diffusion profile. Hence, the present study concluded that the anti-convulsant activity of levetiracetam formulation (F2) shows better activity than the levetiracetam plain.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Evaluation; Levetiracetam; Niosomes; Improved Anti Convulsant Activity |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 02 Jul 2017 10:21 |
| Last Modified: | 02 Jul 2017 10:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/773 |
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