Formulation and Devolopment of Floating Matrix Tablets of Lamivudine.

Pavan Kumar, Bodigalla (2014) Formulation and Devolopment of Floating Matrix Tablets of Lamivudine. Masters thesis, Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, Tamil Nadu, India.


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Oral route is the most desired, convenient and preferred method of administering the drug for its systemic effect due to its ease of administration, low cost of therapy and patient compliance. Oral route of administration has received more attention in the pharmaceutical field because of more flexibility in the designing of dosage form than the other routes of drug delivery. The release of drug from the delivery system may be by diffusion, dissolution or by combination of both mechanisms in a desired and controlled manner. One main prerequisite for the oral performance of the drug delivery system is that drug should have good absorption throughout the gastrointestinal tract (GIT). Amongall the formulations (F1-F11), it was observed that Formulation-10 has shown better dissolution profile. So Formulation-10 was found to be the best formulation when compared with other prepared formulations. The polymers were used at the different concentrations in the formula, much difference were observed in the release characteristics of the floating tablets prepared. The release data were analyzed as per zero order, first order, Higuchi and Korsmeyer & Peppas models. The correlation coefficient (r2) values in the analysis of release data as per various models are mentioned. Analysis of the release data as per zero order and first order kinetic models indicated that the drug release from floating tablets formulated followed First.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation; Devolopment; Floating Matrix Tablets; Lamivudine
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 02 Jul 2017 10:14
Last Modified: 02 Jul 2017 10:14

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