Prabakaran, T (2014) Preparation and Characterization of Transdermal Flims of Non-Steroidal Anti-Inflammatory Drug Ketoprofen. Masters thesis, Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, Tamil Nadu, India.
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Abstract
Topical drug delivery is well-known for the treatment of local skin disorders, but the use of the skin as a route for systemic drug delivery is a more recent development. Very few Transdermal products have been approved to date, largely because of the complexities involved in achieving a consistent delivery rate. There are many variables that influence the absorption of drugs across the skin and into the general circulation, including the biological properties of the skin, chemical properties of the drug, and the interactions between skin and drug delivery system. Systematic studies have led to complications of permeability data for a range of drugs through skin, both stratum corneum and dermis. On the basis of good mechanical properties, better compatibility and stability of drug with polymer, highest drug permeation, we selected film formulation F3 (3% Menthol) for use in In vivo studies. The in vivo studies revealed a significant increase in anti inflammatory effects as compared with conventional gel without menthol. From in vitro and in vivo data it can be concluded that the developed film formulation F3 have great potential for transdermal drug delivery. Developed film formulation F3 has the best effective combination of polymer to achieve therapeutic plasma concentration. But additional experiments should be carried out before the film formulations are used on humans.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Preparation; Characterization; Transdermal Flims; Non Steroidal; Anti Inflammatory Drug; Ketoprofen |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 02 Jul 2017 09:59 |
| Last Modified: | 02 Jul 2017 09:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/769 |
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