Nandhini, T S (2015) Effect of Intravenous Dexmedetomidine on Prolonging Spinal Anesthesia: A Randomised Controlled Study. Masters thesis, ESIC Medical College & Postgraduate Institute of Medical Science and Research, Chennai.
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Abstract
BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the effect of intravenous dexmedetomidine on prolongation of spinal anesthesia. METHODS: Study population comprised of 100 patients scheduled for abdominal/vaginal hysterectomy under spinal anesthesia. 100 adult patients classified as ASA 1 or 2 were studied. Patients were randomly assigned to one of the two groups In Group-D patients received hyperbaric intrathecal bupivacaine anesthesia 3.5ml 0.5% (17.5 mg) and intravenous Dexmedetomidine 0.5micro grams/Kg in10 ml normal saline over 10 minutes after initiation of spinal block. In Group C patients received hyperbaric bupivacaine anaesthesia 3.5 ml 0.5% (17.5mg) and intravenous normal saline 10 ml over 10 minutes. RESULTS: The time for the motor block to become B0 was 243±17.0 minutes in the study group and in the control group it was 211.2±16.7 minutes. The total time for sensory level to reach S1 was 255±8.6in the study group while it was 210.8±33,1 in the control group. The time for two dermatome regression from the maximal level was 125.2±17.5minutes in the study group and 94.6±18.9 in the control group. This proved the significant prolongation of motor block, sensory block, sensory block to regress from the maximal level in the study group with a p value of 0.001***. CONCLUSION: Dexmedetomidine in the dose of 0.5 microgram/kg given as single intravenous dose to patients who underwent abdominal/vaginal hysterectomy under spinal anesthesia significantly prolonged the duration of sensory and motor blockade and also caused arousable sedation.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Intravenous Dexmedetomidine ; Prolonging Spinal Anesthesia ; Randomised Controlled Study. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 07 May 2018 06:32 |
| Last Modified: | 07 May 2018 06:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7614 |
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