Jeyakkumar, R (2015) Oral Bisoprolol Improves Surgical Field in Fess. Masters thesis, Madurai Medical College, Madurai.
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Abstract
BACKGROUND: The success of functional endoscopic sinus surgery (FESS) depends on visual clarity of the surgical field, through the endoscope. The objective of this double-blind, randomized, controlled study was to determine if a pre-operative dose of Bisoprolol (2.5 mg) would reduce the bleeding during FESS and improve the visualization of the operative field. MATERIALS AND METHODS: Sixty American Society of Anesthesiologists I or II patients, scheduled for FESS were randomized to receive either a Placebo (Group A) or 2.5 mg of Bisoprolol (Group B) 90 min prior to the surgery. All the patients received standard anesthesia and monitoring. The aim was to maintain the mean arterial pressure (MAP) of 60-70 mmHg, by titrating dose of Sevflurane and Fentanyl. The concentration of Sevoflurane used was recorded every 10 min. At the end of the surgery, the volume of blood loss was measured and the surgeon was asked to grade the operative field as per the Fromme-Boezaart Scale. RESULT: The blood loss was significantly (P < 0.0001) more in the Control group (97 ± 16.75 ml) as compared with that in the Bisoprolol group (58.3 ± 13.9 ml). The surgical field was graded better in those who received Bisoprolol as compared with those in the Control group (P − 0.0001). The volume percent of Sevoflurane and the dose of Fentanyl used was significantly lower in those who received Bisoprolol. During the operative period, the MAPs were 92.87 ± 6.39 (Group A) and 78.25 ± 3.5 mmHg (Group B) and the heart rate was 94.75 ± 3.14/min (Group A) and 67.97 ± 1.84/min (Group B). These differences were statistically significant (P < 0.001). CONCLUSION: This clinical trial has demonstrated that administration of a single preoperative dose of bisoprolol (2.5 mg) can significantly reduce the blood loss during FESS and improve the visualization of the operating field.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Beta-blocker ; bisoprolol ; blood loss ; functional endoscopic sinus surgery ; surgical field. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 07 May 2018 04:02 |
| Last Modified: | 08 May 2018 06:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7576 |
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